Anti-LGI4 Antibody

The leucine-rich, glioma inactivated gene 4 (LGI4) is a member of the LGI family in which LGI1 is the exemplar. The LGI family consists of four of highly related proteins containing leucine-rich repeats (LRRs) which are highly similar to other transmembrane signaling molecules and receptors. LGI1 has been identified as a candidate tumor suppressor gene for glioma and plays a role in autodominant lateral temporal epilepsy (ADTLE), an epileptic syndrome characterized by focal seizures with predominant auditory symptoms. Despite its high homology with LGI1 and similar pattern of expression, mutations in LGI4 have not been found to be associated with ADTLE. However, the LGI4 gene is located in a region linked to benign familial infantile convulsions.

This antibody recognizes the C-terminus of LGI4.

Epitope: C-terminus

KLH-conjugated linear peptide corresponding to the C-terminus of human LGI4.

Detect the LGI4 protein using this Anti-LGI4 validated for use in WB.

Research Category
Neuroscience

Research Sub Category
Developmental Neuroscience

Evaluated by Western Blot in rat brain tissue lysate.

Western Blot Analysis: 2 µg/mL of this antibody detected LGI4 in 15 µg of rat brain tissue lysate.

~59 kDa observed

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with 0.02% sodium azide.

Stable for 1 year at 2-8°C from date of receipt.

Control
Rat brain tissue lysate

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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