跳转至内容
Merck
CN
所有图片(2)

文件

ABN278

Sigma-Aldrich

抗Prospero同源盒蛋白1/PROX1抗体

from rabbit, purified by affinity chromatography

登录查看公司和协议定价
所有图片(2)
别名:
Prospero homeobox protein 1, Homeobox prospero-like protein PROX1, PROX-1
UNSPSC代码:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物来源

rabbit

质量水平

100

抗体形式

affinity isolated antibody

抗体产品类型

primary antibodies

克隆

polyclonal

纯化方式

affinity chromatography

种属反应性

mouse, rat

种属反应性（根据同源性预测）

bovine (based on 100% sequence homology), fish (based on 100% sequence homology), chicken (based on 100% sequence homology), human (based on 100% sequence homology)

技术

immunohistochemistry: suitable
western blot: suitable

NCBI登记号

NP_001257545

UniProt登记号

Q92786

运输

wet ice

靶向翻译后修饰

unmodified

基因信息

mouse ... Prox1(19130)

一般描述

PROX1（Prospero同源盒蛋白1）是果蝇Prospero的同源物，是一种含有同源盒的转录因子，可结合并充当肝受体同源物1（LRH1/NR5A2）的共受体。它是淋巴内皮细胞以及成肝细胞和肝细胞的特异性标志物。人Prox1与小鼠和大鼠Prox1具有97%的氨基酸序列一致性。

免疫原

KLH偶联的线性肽，对应于人Prospero同源盒蛋白1/PROX1的C末端。

应用

免疫组化分析：代表性批次的1：2,000的稀释液在小鼠E16胚胎丘脑组织中检测到Prospero同源盒蛋白1/PROX1（Prof. Samual Pleasure, University of California, San Francisco.）。

Alexa Fluor™是Life Technologies，Inc.的注册商标。
该抗Prospero同源盒蛋白1/PROX1抗体经验证可用于蛋白质印迹&IHC检测Prospero同源盒蛋白1/PROX1。

质量

通过蛋白质印迹在HEK293核提取物中进行了评估。

蛋白质印迹分析：该抗体的1：500稀释液在10 µg HEK293核提取物中检测到Prospero同源盒蛋白1/Prox1。

目标描述

观察值〜95 kDa。Uniprot描述了83kDa的分子量，然而，由于SUMO化和/或替代起始位点，可在80-110kDa之间观察到该蛋白（Pan，M.R.，et al.（2009）.J Cell Sci. 122(Pt18):3358-3361.; Azuma, K., et al. (2011).Genes Cells.16(11):1063-1070.)。

联系

替代品：AB5475

法律信息

ALEXA FLUOR is a trademark of Life Technologies

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Charlotte M Ermine et al.
Journal of neuroscience research, 99(12), 3222-3237 (2021-10-16)
Animal modeling has played an important role in our understanding of the pathobiology of stroke. The vast majority of this research has focused on the acute phase following severe forms of stroke that result in clear behavioral deficits. Human stroke
Charlotte M Ermine et al.
Hippocampus, 28(5), 327-337 (2018-02-13)
Key pathological features of Parkinson's Disease (PD) include the progressive degeneration of midbrain dopaminergic (DA) neurons and hindbrain noradrenergic (NA) neurons. The loss of DA neurons has been extensively studied and is the main cause of motor dysfunction. Importantly, however
Lu M Yang et al.
PLoS genetics, 15(7), e1008254-e1008254 (2019-07-06)
The mouse organ of Corti, housed inside the cochlea, contains hair cells and supporting cells that transduce sound into electrical signals. These cells develop in two main steps: progenitor specification followed by differentiation. Fibroblast Growth Factor (FGF) signaling is important
In-Young Choi et al.
Frontiers in molecular neuroscience, 15, 917598-917598 (2022-07-26)
Anxiety disorder is one of the most common comorbidities in temporal lobe epilepsy (TLE), but its neurobiological mechanisms remain unclear. Here we identified a novel target, interleukin-17A (IL-17A), which can contribute to TLE-associated anxiety. Epileptic seizures were induced in 6-week-old
In-Young Choi et al.
JCI insight, 9(1) (2024-01-09)
Prolonged seizures can disrupt stem cell behavior in the adult hippocampus, an important brain structure for spatial memory. Here, using a mouse model of pilocarpine-induced status epilepticus (SE), we characterized spatiotemporal expression of Lin28a mRNA and proteins after SE. Unlike

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门