ABN174
抗-MNX1 （HB9）抗体
from rabbit, purified by affinity chromatography
别名:
Motor neuron and pancreas homeobox protein 1, Homeobox protein HB9
产品名称
抗-MNX1 （HB9）抗体, from rabbit, purified by affinity chromatography
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
mouse, human
technique(s)
immunohistochemistry: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... MNX1(3110)
Analysis Note
对照
PANC-1 细胞裂解液
PANC-1 细胞裂解液
通过蛋白质印迹对PANC-1细胞裂解液进行了评估。
蛋白质印迹分析：0.5 µg/mL该抗体在10 µg 人PANC-1 细胞裂解物中检测到MNX1。
蛋白质印迹分析：0.5 µg/mL该抗体在10 µg 人PANC-1 细胞裂解物中检测到MNX1。
Application
免疫组化分析： 一个代表性批次的1：1,000稀释液在人胰腺和小鼠大脑皮层组织中检测到MNX1 。
抗-MNX1 （HB9）抗体可检测MNX1 （HB9）水平，&已有相关文献发表 &经验证可用于蛋白质印迹&IHC。
研究子类别
转录因子
转录因子
研究类别
神经科学
神经科学
Biochem/physiol Actions
其他同源性：斑马鱼（94%序列同源性）和非洲爪蟾（89%序列同源性）。
该抗体识别同源盒DNA结合结构域的一部分。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
观察值〜50 kDa。 在一些裂解液中约48 kDa处可能出现一个未表征的条带。
运动神经元和胰腺同源盒蛋白1 （MNX1）是一种转录因子，主要在淋巴和胰腺组织中表达。它涉及胰腺的发育和功能。MNX1 的异常表达导致一种常染色体显性遗传病Currarino综合征。
Immunogen
对应于人MNX1的KLH偶联线性肽。
Other Notes
浓度：请参考批次特异性浓缩物的检验报告。
Physical form
亲和纯化
纯化的兔多克隆抗体，溶于含有0.1 M Tris-甘氨酸（pH 7.4）、150 mM NaCl和0.05％叠氮化钠的缓冲液中。
Preparation Note
自收到之日起，在2-8°C条件下可稳定保存1年。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Gonzalo Perez-Siles et al.
Disease models & mechanisms, 13(2) (2020-01-24)
ATP7A encodes a copper-transporting P-type ATPase and is one of 23 genes in which mutations produce distal hereditary motor neuropathy (dHMN), a group of diseases characterized by length-dependent axonal degeneration of motor neurons. We have generated induced pluripotent stem cell
G Perez-Siles et al.
Scientific reports, 10(1), 9262-9262 (2020-06-07)
Charcot-Marie-Tooth (CMT) is a group of inherited diseases clinically and genetically heterogenous, characterised by length dependent degeneration of axons of the peripheral nervous system. A missense mutation (p.R158H) in the pyruvate dehydrogenase kinase 3 gene (PDK3) has been identified as
Daehwan Kim et al.
Translational neurodegeneration, 11(1), 16-16 (2022-03-12)
Amyotrophic lateral sclerosis (ALS) is characterized by a progressive loss of motor neurons (MNs), leading to paralysis, respiratory failure and death within 2-5 years of diagnosis. The exact mechanisms of sporadic ALS, which comprises 90% of all cases, remain unknown. In
Andrew Wang et al.
BMC endocrine disorders, 21(1), 185-185 (2021-09-15)
Cushing's disease (CD) is defined as hypercortisolemia caused by adrenocorticotropic hormone (ACTH)-secreting pituitary adenomas (corticotroph PA) that afflicts humans and dogs. In order to map common aberrant genomic features of CD between humans and dogs, we performed genomic sequencing and
Ilary Allodi et al.
Scientific reports, 6, 25960-25960 (2016-05-18)
The fatal disease amyotrophic lateral sclerosis (ALS) is characterized by the loss of somatic motor neurons leading to muscle wasting and paralysis. However, motor neurons in the oculomotor nucleus, controlling eye movement, are for unknown reasons spared. We found that
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