所有图片(1)
Class E basic helix-loop-helix protein 40, bHLHe40, Class B basic helix-loop-helix protein 2, bHLHb2, Differentially expressed in chondrocytes protein 1, DEC1, Enhancer-of-split and hairy-related protein 2, SHARP-2, Stimulated by retinoic acid gene 13 pr
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生物来源
rabbit
质量水平
抗体形式
serum
抗体产品类型
primary antibodies
克隆
polyclonal
种属反应性
human
种属反应性(根据同源性预测)
rhesus macaque (based on 100% sequence homology), rat (based on 100% sequence homology), horse (based on 100% sequence homology), canine (based on 100% sequence homology), bovine (based on 100% sequence homology), mouse (based on 100% sequence homology)
技术
western blot: suitable
NCBI登记号
UniProt登记号
运输
dry ice
靶向翻译后修饰
unmodified
基因信息
human ... BHLHE40(8553) , DEC1(50514) , STRA13(201254)
一般描述
Class E basic helix-loop-helix protein 40 (UniProt O14503; also known as Basic helix-loop-helix domain containing class B2, Class B basic helix-loop-helix protein 2, Differentially expressed in chondrocytes 1, Differentially expressed in chondrocytes protein 1, Differentiated embryo chondrocyte expressed gene 1, Enhancer-of-split and hairy-related protein 2, SHARP-2, Stimulated by retinoic acid gene 13 protein) is encoded by the BHLHE40 (also known as BHLHB2, DEC1, HLHB2, SHARP2, STRA13) gene (Gene ID 8553) in human. DEC1 (differentially expressed in chondrocytes 1) and DEC2 are E-box-binding transcription factors that exhibit a circadian expression pattern. Both proteins act to repress the Clock/Bmal1-activated E-box promoters via direct E-box binding rather than Bmal1 interaction. In addition, DEC1 is shown to negatively regulate the expression of DEC2. Markedly increased DEC1 expression is observed in colon carcinomas, whereas the opposite trend is seen with DEC2. Likewise cellular DEC1 over-expression results in a proportional decrease in DEC2 level.
免疫原
Epitope: N-terminal
KLH-conjugated linear peptide corresponding to human BHLHE40/DEC1.
应用
Anti-BHLHE40/DEC1 Antibody is an antibody against BHLHE40/DEC1 for use in Western Blotting.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Developmental Neuroscience
Developmental Neuroscience
质量
Evaluated by Western Blotting in K562 nuclear extract.
Western Blotting Analysis: A 1:500 dilution of this antibody detected BHLHE40/DEC1 in 10 µg of K562 nuclear extract.
Western Blotting Analysis: A 1:500 dilution of this antibody detected BHLHE40/DEC1 in 10 µg of K562 nuclear extract.
目标描述
~48 kDa observed. Uncharacterized band(s) may appear in some lysates.
外形
Unpurified
Rabbit polyclonal serum with 0.05% sodium azide.
储存及稳定性
Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
其他说明
Concentration: Please refer to lot specific datasheet.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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