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一般描述
Special AT-rich sequence-binding protein 2 (SATB2) contains 2 CUT DNA-binding domains and one homeobox DNA binding domain belonging to the CUT homeobox family. SATB2 binds to DNA at the nuclear matri or scaffold-associated regions. SATB2 is highly expressed in adult brain, moderately expressed in fetal brain, and weakly expressed in adult liver, kidney, and spinal cord. Mutations in SATB2 have been associated with cleft palate.
特异性
This antibody recognizes the N-terminus of SATB2.
免疫原
Epitope: N-terminus
KLH-conjugated linear peptide corresponding to the N-terminus of human SATB2.
应用
Detect Special AT-rich sequence-binding protein 2 using this rabbit polyclonal antibody, Anti-SATB2 Antibody validated for use in western blotting, IHC (Paraffin) & Immunofluorescence.
Immunohistochemistry Analysis: 5 µg/mL from a representative lot detected SATB2 in human brain tissue.
Immunofluorescence Analysis: 20 μg/mL from a representative lot detected SATB2 in human brain cells.
Immunofluorescence Analysis: 20 μg/mL from a representative lot detected SATB2 in human brain cells.
Research Category
Epigenetics & Nuclear Function
Epigenetics & Nuclear Function
Research Sub Category
Transcription Factors
Transcription Factors
质量
Evaluated by Western Blotting in mouse brain tissue lysate.
Western Blotting Analysis: 4 µg/mL of this antibody detected SATB2 in 15 µg of mouse brain tissue lysate.
Western Blotting Analysis: 4 µg/mL of this antibody detected SATB2 in 15 µg of mouse brain tissue lysate.
目标描述
~90 kDa observed
外形
Antigen Affinity Purified
Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
储存及稳定性
Stable for 1 year at 2-8°C from date of receipt.
分析说明
Control
Mouse brain tissue lysate
Mouse brain tissue lysate
其他说明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Lei Wang et al.
Nature neuroscience, 19(7), 888-896 (2016-05-24)
The unique mental abilities of humans are rooted in the immensely expanded and folded neocortex, which reflects the expansion of neural progenitors, especially basal progenitors including basal radial glia (bRGs) and intermediate progenitor cells (IPCs). We found that constitutively active
Lei Wang et al.
Proceedings of the National Academy of Sciences of the United States of America, 119(38), e2206147119-e2206147119 (2022-09-13)
The neocortex, the center for higher brain function, first emerged in mammals and has become massively expanded and folded in humans, constituting almost half the volume of the human brain. Primary microcephaly, a developmental disorder in which the brain is
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