推荐产品
生物来源
rabbit
抗体形式
purified antibody
抗体产品类型
primary antibodies
克隆
polyclonal
种属反应性（根据同源性预测）
all
技术
ChIP: suitable
RIP: suitable
dot blot: suitable
运输
wet ice
靶向翻译后修饰
unmodified
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此商品 | PHR1006 | S3889 | 85529 |
|---|---|---|---|
| form viscous liquid | form - | form powder | form powder |
| color colorless | color - | color white | color colorless |
| concentration 70 wt. % in H2O | concentration - | concentration - | concentration - |
| refractive index n20/D 1.46 | refractive index - | refractive index - | refractive index - |
| density 1.28 g/mL at 25 °C | density - | density - | density - |
一般描述
N6-甲基腺苷（m6A），或腺苷N6位的甲基化，是RNA的一种转录后修饰。 由于分析方法的缺乏，人们对N6-甲基腺苷了解的很少，但新证据表明它是一种非常常见的碱基修饰和重要的生理调节因子。N6-甲基腺苷在整个大脑发育过程中都会显著增加，并会在终止密码子、microRNA结合位点和UTR附近富集，表明了其在基因表达调节中的基础性作用。N6-甲基腺苷在人和小鼠之间也高度保守。
免疫原
BSA偶联的N6-甲基腺苷。
应用
染色质免疫沉淀分析：A representative lot from an independent laboratory detected N6-methyladenosine in RNA containing N6-methyladenosine (Dominissini, D., et al. (2012).Nature.485(7397):201-206.; Meyer, K. D., et al. (2012).Cell.149(7):1635-1646.).
(RNA) Immunoprecipitation Analysis: A representative lot from an independent laboratory detected N6-methyladenosine in methylated RNA containing N6-methyladenosine (Meyer, K. D., et al. (2012).Cell.149(7):1635-1646.).
Dot Blot Analysis: A representative lot from an independent laboratory detected N6-methyladenosine in a panel of modified oligonucleotides (Meyer, K. D., et al. (2012).Cell.149(7):1635-1646.; Jia, G., et al. (2011).Nat Chem Biol. 7(12):885-887.).
(RNA) Immunoprecipitation Analysis: A representative lot from an independent laboratory detected N6-methyladenosine in methylated RNA containing N6-methyladenosine (Meyer, K. D., et al. (2012).Cell.149(7):1635-1646.).
Dot Blot Analysis: A representative lot from an independent laboratory detected N6-methyladenosine in a panel of modified oligonucleotides (Meyer, K. D., et al. (2012).Cell.149(7):1635-1646.; Jia, G., et al. (2011).Nat Chem Biol. 7(12):885-887.).
研究子类别
染色质生物学
染色质生物学
研究类别
表观遗传学&核功能
表观遗传学&核功能
通过使用已验证用于斑点印迹、染色质IP（ChIP) & RNA结合蛋白IP（RIP）的抗-N6-甲基腺苷（m6A）抗体检测N6-甲基腺苷（m6A）。
质量
已通过斑点印迹在含有N6-甲基腺苷的低聚物中进行评估。
斑点印迹分析： 1 µg/mL的该抗体可在含有N6-甲基腺苷的低聚物中检测到N6-甲基腺苷。
斑点印迹分析： 1 µg/mL的该抗体可在含有N6-甲基腺苷的低聚物中检测到N6-甲基腺苷。
外形
在含有0.05%叠氮化钠PBS的缓冲液中的纯化兔多抗。
形式：纯化
纯化的蛋白 A
储存及稳定性
自发运之日起，在 2-8°C 条件下可稳定保存1年
其他说明
浓度：请参考批次特异性浓缩物的分析证书。
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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储存分类代码
10 - Combustible liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Xiaoling Liu et al.
Analytical chemistry, 90(9), 5546-5551 (2018-04-14)
N6-methyladenine (6mA) is a rediscovered DNA modification in eukaryotic genomes. To explore the distribution and functions of 6mA, it is of paramount option to use immunoprecipitation to select 6mA-containing DNA fragments for genome-wide sequencing. Presumably, most of the 6mA-free fragments
Taylor M Nye et al.
PLoS pathogens, 15(6), e1007841-e1007841 (2019-06-18)
DNA methylation is pervasive across all domains of life. In bacteria, the presence of N6-methyladenosine (m6A) has been detected among diverse species, yet the contribution of m6A to the regulation of gene expression is unclear in many organisms. Here we
Hua Su et al.
BMC genomics, 21(1), 39-39 (2020-01-15)
Hypoxia mediated pulmonary hypertension (HPH) is a lethal disease and lacks effective therapy. CircRNAs play significant roles in physiological process. Recently, circRNAs are found to be m6A-modified. The abundance of circRNAs was influenced by m6A. Furthermore, the significance of m6A
Weili Miao et al.
Nature communications, 10(1), 3613-3613 (2019-08-11)
Small-molecule inhibitors for the 90-kDa heat shock protein (HSP90) have been extensively exploited in preclinical studies for the therapeutic interventions of human diseases accompanied with proteotoxic stress. By using an unbiased quantitative proteomic method, we uncover that treatment with three
Bastian Linder et al.
Nature methods, 12(8), 767-772 (2015-06-30)
N(6)-methyladenosine (m6A) is the most abundant modified base in eukaryotic mRNA and has been linked to diverse effects on mRNA fate. Current mapping approaches localize m6A residues to transcript regions 100-200 nt long but cannot identify precise m6A positions on
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