ABE542
抗-YTHDF2抗体
from rabbit, purified by affinity chromatography
别名:
YTH domain-containing family protein 2, CLL-associated antigen KW-14, High-glucose-regulated protein 8, Renal carcinoma antigen NY-REN-2
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
immunocytochemistry
western blot
western blot
Species reactivity:
human, rat
Citations:
9
Technique(s):
immunocytochemistry: suitable
western blot: suitable
western blot: suitable
Uniprot accession no.:
产品名称
抗-YTHDF2抗体, from rabbit, purified by affinity chromatography
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
human, rat
technique(s)
immunocytochemistry: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... YTHDF2(51441)
Analysis Note
通过蛋白质印迹对C6细胞裂解液进行了评估。
蛋白质印迹分析：1.0 µg/mL该抗体可在10 µg的C6细胞裂解液中检测到YTHDF2。
蛋白质印迹分析：1.0 µg/mL该抗体可在10 µg的C6细胞裂解液中检测到YTHDF2。
Application
研究子类别
核受体
核受体
研究类别
表观遗传学&核功能
表观遗传学&核功能
蛋白印迹分析：15 µg/mL代表性批次在WT HeLa细胞裂解物和YTHDF2过表达裂解物中检测到YTHDF2（Chuan He，University of Chicago）。
免疫细胞化学分析：来自代表性批次的1：200稀释液在HeLa细胞中检测到YTHDF2（Chuan He，Univerity of Chicago）。
免疫细胞化学分析：来自代表性批次的1：200稀释液在HeLa细胞中检测到YTHDF2（Chuan He，Univerity of Chicago）。
该抗YTHDF2抗体经过验证可用在 WB，IC 中检测YTHDF2。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
含有YTH结构域的家族蛋白2（YTHDF2），也称为CLL相关抗原KW-14，高葡萄糖调节蛋白8，肾癌抗原NY-REN-2，也由基因名YTHDF2和HGRG8编码。YTHDF2特异性识别并结合含N6-甲基腺苷（m6A）的RNA。M6A是存在于mRNA和一些非编码RNA内部位点的修饰。最近的研究表明，YTHDF2可能在mRNA剪接、加工和稳定性的效率中起重要作用。另外，已显示YTHDF2充当mRNA稳定性的调节剂。 并且在与含m6A的mRNA结合的过程中，认为YTHDF2定位于mRNA衰变位点，例如处理小体（P小体），从而导致mRNA降解。
观察值〜62 kDa。某些裂解液可能会出现未表征的条带。
Immunogen
KLH偶联线性肽对应于mRNA处理小体（P小体）对于人YTHDF2的定位。
表位：定位于mRNA处理小体（P小体）
Other Notes
浓度：请参考特定批次的数据表。
Physical form
亲和纯化
在含 0.1 M Tris-甘氨酸（pH 7.4），150 mM NaCl 和 0.05％ 叠氮化钠的缓冲液中的纯化的兔多克隆抗体。
Preparation Note
自收到之日起，在 2-8°C 条件下可稳定保存1年
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Xinxia Wang et al.
International journal of obesity (2005), 42(11), 1912-1924 (2018-03-01)
N6-methyladenosine (m6A) modification of mRNA plays an important role in regulating adipogenesis. However, its underlying mechanism remains largely unknown. Using Jinhua and Landrace pigs as fat and lean models, we presented a comprehensive transcriptome-wide m6A profiling in adipose tissues from
Ruifan Wu et al.
Cell death & disease, 10(3), 171-171 (2019-02-23)
Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) hold great promise for regenerative medicine, disease treatment, and organ transplantation. As the ethical issue of human ESCs and similarity of pig in human genome and physiological characteristics, the porcine
Lin Yang et al.
Communications biology, 5(1), 495-495 (2022-05-26)
The chondrogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) has been used in the treatment and repair of cartilage defects; however, the in-depth regulatory mechanisms by which RNA modifications are involved in this process are still poorly understood. Here
Sarah N'Da Konan et al.
Retrovirology, 19(1), 4-4 (2022-02-02)
The recent discovery of the role of m6A methylation in the regulation of HIV-1 replication unveiled a novel layer of regulation for HIV gene expression. This epitranscriptomic modification of HIV-1 RNAs is under the dynamic control of specific writers and
Angelica Benavides-Serrato et al.
Cancer letters, 562, 216178-216178 (2023-04-16)
A major mechanism conferring resistance to mTOR inhibitors is activation of a salvage pathway stimulating internal ribosome entry site (IRES)-mediated mRNA translation, driving the synthesis of proteins promoting resistance of glioblastoma (GBM). Previously, we found this pathway is stimulated by
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