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产品名称
抗-c-Fos抗体, from rabbit, purified by affinity chromatography
生物来源
rabbit
质量水平
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
纯化方式
affinity chromatography
种属反应性
human, rat
种属反应性（根据同源性预测）
sheep (based on 100% sequence homology), mouse (based on 100% sequence homology), bovine (based on 100% sequence homology), rhesus macaque (based on 100% sequence homology), chimpanzee (based on 100% sequence homology), porcine (based on 100% sequence homology)
技术
immunohistochemistry: suitable (paraffin)
western blot: suitable
NCBI登记号
UniProt登记号
运输
wet ice
靶向翻译后修饰
unmodified
基因信息
human ... FOS(2353)
一般描述
c-Fos是也被鉴定为原癌基因的立即早期基因（IEG）转录因子家族的成员（其他成员包括Jun和Egr-1）。c-Fos和其他IEG的基础表达通常较低，但响应通常由外部刺激（例如应激或神经元激活）引起的细胞活性变化而相对快速且通常急剧增加（mRNA为15-30分钟；蛋白为30-60分钟）。因此，这些IEG用于指示比活驱动的细胞活化，包括鉴别由各种生长因子、神经活性药物激活的神经元以及行为或生理状态的相关变化。
特异性
该抗体识别c-Fos的N末端。
免疫原
对应于人c-Fos N末端的KLH偶联的线性肽。
应用
免疫组化分析： 代表性批次的1：1,000稀释液在大鼠脑桥和大鼠小脑组织中检测到c-Fos。
免疫荧光分析： 代表性批次在大鼠脑桥和大鼠小脑组织中检测到c-Fos。
免疫荧光分析： 代表性批次在大鼠脑桥和大鼠小脑组织中检测到c-Fos。
抗c-Fos抗体是一种用于检测c-Fos的兔多克隆抗体，也称为原癌基因c-Fos，细胞癌基因fos&已在WB &IHC中得到验证。
质量
通过蛋白质印迹在PMA（TPA）处理的HeLa细胞裂解物中的进行了评估。
蛋白质印迹分析：0.5 µg/mL该抗体在10 µg PMA（TPA）处理的HeLa细胞裂解物中检测到c-Fos。
蛋白质印迹分析：0.5 µg/mL该抗体在10 µg PMA（TPA）处理的HeLa细胞裂解物中检测到c-Fos。
目标描述
观察值〜60/56 kDa。 该蛋白具有通过53和68kDa范围内的选择性剪接产生的多种亚型（Jurado, J., et al. (2007).BMC Molecular Biology.8:83-96.)
分析说明
对照
PMA（TPA）处理的HeLa细胞裂解物
PMA（TPA）处理的HeLa细胞裂解物
其他说明
浓度：请参考批次特异性浓缩物的分析证书。
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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