ABE431
Anti-PTBP2 Antibody
from rabbit, purified by affinity chromatography
别名:
Polypyrimidine tract-binding protein 2, Neural polypyrimidine tract-binding protein, Neurally-enriched homolog of PTB, PTB-like protein
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
immunoprecipitation (IP)
western blot
western blot
Species reactivity:
mouse, human, rat
Citations:
4
Technique(s):
immunoprecipitation (IP): suitable
western blot: suitable
western blot: suitable
Uniprot accession no.:
产品名称
Anti-PTBP2 Antibody, from rabbit, purified by affinity chromatography
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
mouse, human, rat
species reactivity (predicted by homology)
canine (based on 100% sequence homology), gorilla (based on 100% sequence homology), bovine (based on 100% sequence homology), rhesus macaque (based on 100% sequence homology)
technique(s)
immunoprecipitation (IP): suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... PTBP2(58155)
Analysis Note
Control
Human cortex tissue lysate
Human cortex tissue lysate
Evaluated by Western Blotting in human cortex tissue lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected PTBP2 in 10 µg of human cortex tissue lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected PTBP2 in 10 µg of human cortex tissue lysate.
Application
Anti-PTBP2 Antibody is a highly specific rabbit polyclonal antibody, that targets Polypyrimidine tract-binding protein 2 & has been tested in western blotting & IP.
Research Category
Epigenetics & Nuclear Function
Epigenetics & Nuclear Function
Research Sub Category
Transcription Factors
Transcription Factors
Western Blotting Analysis: 0.5 µg/mL from a representative lot detected PTBP2 in 10 µg of rat brain cortex tissue lysate.
Immunoprecipitation Analysis: 10ug from a representative lot immunoprecipitated PTBP2 in 500 µg of P19 cell lysate.
Immunoprecipitation Analysis: 10ug from a representative lot immunoprecipitated PTBP2 in 500 µg of P19 cell lysate.
Biochem/physiol Actions
This antibody recognizes the N-terminus of PTBP2.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Polypyrimidine tract-binding protein 2 (PTBP2) is also known as Neural polypyrimidine tract-binding protein, Neurally-enriched homolog of PTB and PTB-like protein. PTBP2 is a RNA-binding protein which targets intronic polypyrimidines and negatively regulates pre-mRNA, exonic splicing. PTBP2 also has a role in translational regulation. PTBP2 is mainly expressed in brain, but is also found in heart and skeletal muscle. Isoforms 1 and 2 are specifically expressed in neuronal tissues.
~57 kDa observed. Uncharacterized band(s) may appear in some lysates.
Immunogen
Epitope: N-terminus
KLH-conjugated linear peptide corresponding to the N-terminus of human PTBP2.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Physical form
Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Linda Yip et al.
Diabetes, 64(2), 604-617 (2014-09-05)
Peripheral tolerance is partially controlled by the expression of peripheral tissue antigens (PTAs) in lymph node stromal cells (LNSCs). We previously identified a transcriptional regulator, deformed epidermal autoregulatory factor 1 (Deaf1), that can regulate PTA expression in LNSCs of the
Runwei Yang et al.
Neuron, 111(10), 1637-1650 (2023-03-15)
The Ras GTPase-activating protein SYNGAP1 plays a central role in synaptic plasticity, and de novo SYNGAP1 mutations are among the most frequent causes of autism and intellectual disability. How SYNGAP1 is regulated during development and how to treat SYNGAP1-associated haploinsufficiency
Jennine M Dawicki-McKenna et al.
Nature communications, 14(1), 2628-2628 (2023-05-07)
Alternative splicing of neuronal genes is controlled partly by the coordinated action of polypyrimidine tract binding proteins (PTBPs). While PTBP1 is ubiquitously expressed, PTBP2 is predominantly neuronal. Here, we define the PTBP2 footprint in the human transcriptome using brain tissue
Ainara Elorza et al.
Brain : a journal of neurology, 144(7), 2009-2023 (2021-03-17)
Correction of mis-splicing events is a growing therapeutic approach for neurological diseases such as spinal muscular atrophy or neuronal ceroid lipofuscinosis 7, which are caused by splicing-affecting mutations. Mis-spliced effector genes that do not harbour mutations are also good candidate
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