推荐产品
生物来源
rabbit
质量水平
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
纯化方式
affinity chromatography
种属反应性
mouse, human, rat
技术
immunocytochemistry: suitable
immunohistochemistry: suitable (paraffin)
western blot: suitable
NCBI登记号
UniProt登记号
运输
wet ice
靶向翻译后修饰
unmodified
基因信息
human ... TET2(54790)
一般描述
甲基胞嘧啶双加氧酶TET2催化甲基胞嘧啶（5mC）向5-羟甲基胞嘧啶（5hmC）的转化。目前尚不清楚5-羟甲基胞嘧啶的功能，但它可能影响染色质结构，或充当胞嘧啶去甲基化的中间成分。TET2在骨髓增生性疾病（MPD）或骨髓增生性肿瘤（MPN）和全身性肥大细胞增生症中经常发生突变。TET2紊乱还会导致真性红细胞增多症（PV）和骨髓异常增生综合征（MDS）。
免疫原
KLH偶联线性肽对应于人Tet2。
应用
免疫组化分析：代表性批次的1：4,000稀释液在鼠髓质组织中检测到Tet2。
免疫细胞化学分析：代表性批次的1：100稀释液在人H9胚胎干细胞中检测到Tet2。
免疫细胞化学分析：代表性批次的1：100稀释液在人H9胚胎干细胞中检测到Tet2。
抗-Tet2可检测Tet2蛋白的水平&已发表&经验证可用于WB，IHC& ICC。
质量
通过蛋白质印迹在小鼠胚胎干细胞中进行了评估。
蛋白质印迹分析：1 µg/mL该抗体在10 µg小鼠胚胎干细胞中检测到Tet2。（注意：在低浓度或更长暴露时间下可观察到亚型2和3，而在某些细胞裂解液中可在更高浓度或更长暴露时间下检测到亚型1）。
蛋白质印迹分析：1 µg/mL该抗体在10 µg小鼠胚胎干细胞中检测到Tet2。（注意：在低浓度或更长暴露时间下可观察到亚型2和3，而在某些细胞裂解液中可在更高浓度或更长暴露时间下检测到亚型1）。
目标描述
观察值〜140 kDa。已知存在223 kDa（亚型1），133 kDa（亚型2）和133 kDa（亚型3）的三个亚型。该抗体应基于序列同源性识别全部三种亚型。在某些细胞裂解物中，在〜36 kDa处可能观察到未表征的条带。（注意：亚型2和3可能在低浓度下观察到，而亚型1可能在某些细胞裂解物中以较高浓度检测到。）
其他说明
浓度：请参考批次特异性浓缩物的分析证书。
未找到合适的产品？
试试我们的产品选型工具.
储存分类代码
12 - Non Combustible Liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Sherry X Yang et al.
Journal of hematology & oncology, 14(1), 83-83 (2021-05-28)
Challenges remain on the selection of patients who potentially respond to a class of drugs that target epigenetics for cancer treatment. This study aims to investigate TET2/DNMT3A mutations and antitumor activity of a novel epigenetic agent in multiple human cancer
Yunpeng Zhang et al.
Evidence-based complementary and alternative medicine : eCAM, 2019, 1282085-1282085 (2019-11-28)
In addition to abnormalities of motor and posture, children with cerebral palsy (CP) often have intellectual disability. As a complementary and alternative traditional Chinese medicine (TCM) therapy, Chinese Tuina massage, also called Tuina in China, has been widely applied in
Yun Liu et al.
Molecular pain, 18, 17448069221143671-17448069221143671 (2022-11-23)
DNA hydroxylation catalyzed by Tet dioxygenases occurs abundantly in neurons in mammals. However, effects of ten-eleven translocation methylcytosine dioxygenase 1 (TET1) expression and hydroxymethylation status on neuron injury remain unclear. This study was designed to explore the effects of TET1
Jiajie Tu et al.
Stem cell research & therapy, 9(1), 71-71 (2018-03-23)
The regulatory role of long noncoding RNAs (lncRNAs) have been partially proved in embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). In the current study, we investigated mouse ESC (mESC) self-renewal, differentiation, and proliferation in vitro by knocking
Yan-Yan Wu et al.
Neuroscience bulletin, 38(4), 359-372 (2021-12-11)
Irritable bowel syndrome is a gastrointestinal disorder of unknown etiology characterized by widespread, chronic abdominal pain associated with altered bowel movements. Increasing amounts of evidence indicate that injury and inflammation during the neonatal period have long-term effects on tissue structure
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门