推荐产品
生物来源
rabbit
质量水平
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
纯化方式
affinity chromatography
种属反应性
mouse, human, rat
技术
immunocytochemistry: suitable
immunohistochemistry: suitable (paraffin)
western blot: suitable
NCBI登记号
UniProt登记号
运输
wet ice
靶向翻译后修饰
unmodified
基因信息
human ... TET2(54790)
一般描述
甲基胞嘧啶双加氧酶TET2催化甲基胞嘧啶（5mC）向5-羟甲基胞嘧啶（5hmC）的转化。目前尚不清楚5-羟甲基胞嘧啶的功能，但它可能影响染色质结构，或充当胞嘧啶去甲基化的中间成分。TET2在骨髓增生性疾病（MPD）或骨髓增生性肿瘤（MPN）和全身性肥大细胞增生症中经常发生突变。TET2紊乱还会导致真性红细胞增多症（PV）和骨髓异常增生综合征（MDS）。
免疫原
KLH偶联线性肽对应于人Tet2。
应用
免疫组化分析：代表性批次的1：4,000稀释液在鼠髓质组织中检测到Tet2。
免疫细胞化学分析：代表性批次的1：100稀释液在人H9胚胎干细胞中检测到Tet2。
免疫细胞化学分析：代表性批次的1：100稀释液在人H9胚胎干细胞中检测到Tet2。
抗-Tet2可检测Tet2蛋白的水平&已发表&经验证可用于WB，IHC& ICC。
质量
通过蛋白质印迹在小鼠胚胎干细胞中进行了评估。
蛋白质印迹分析：1 µg/mL该抗体在10 µg小鼠胚胎干细胞中检测到Tet2。（注意：在低浓度或更长暴露时间下可观察到亚型2和3，而在某些细胞裂解液中可在更高浓度或更长暴露时间下检测到亚型1）。
蛋白质印迹分析：1 µg/mL该抗体在10 µg小鼠胚胎干细胞中检测到Tet2。（注意：在低浓度或更长暴露时间下可观察到亚型2和3，而在某些细胞裂解液中可在更高浓度或更长暴露时间下检测到亚型1）。
目标描述
观察值〜140 kDa。已知存在223 kDa（亚型1），133 kDa（亚型2）和133 kDa（亚型3）的三个亚型。该抗体应基于序列同源性识别全部三种亚型。在某些细胞裂解物中，在〜36 kDa处可能观察到未表征的条带。（注意：亚型2和3可能在低浓度下观察到，而亚型1可能在某些细胞裂解物中以较高浓度检测到。）
其他说明
浓度：请参考批次特异性浓缩物的分析证书。
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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Journal of hematology & oncology, 14(1), 83-83 (2021-05-28)
Challenges remain on the selection of patients who potentially respond to a class of drugs that target epigenetics for cancer treatment. This study aims to investigate TET2/DNMT3A mutations and antitumor activity of a novel epigenetic agent in multiple human cancer
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In addition to abnormalities of motor and posture, children with cerebral palsy (CP) often have intellectual disability. As a complementary and alternative traditional Chinese medicine (TCM) therapy, Chinese Tuina massage, also called Tuina in China, has been widely applied in
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Cerebral palsy (CP) is a neurodevelopmental disorder usually occurring early in life and persisting through the whole life. Several risk factors, including perinatal hypoxia-ischemia (HI), may contribute to occurrence of CP in preterm infants. DNA hydroxymethylation has been shown to
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