ABE305
Anti-trimethyl Histone H3 (Lys36) Antibody
from rabbit, purified by affinity chromatography
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所有图片(5)
别名:
Histone H3.1, Histone H3/a, Histone H3/b, Histone H3/c, Histone H3/d, Histone H3/f, Histone H3/h, Histone H3/I, Histone H3/j, Histone H3/k, Histone H3/l, H3k36me3
UNSPSC代码:
12352203
eCl@ss:
32160702
NACRES:
NA.41
推荐产品
生物来源
rabbit
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
纯化方式
affinity chromatography
种属反应性
mouse, human
技术
ChIP: suitable
dot blot: suitable
immunocytochemistry: suitable
western blot: suitable
NCBI登记号
UniProt登记号
运输
wet ice
靶向翻译后修饰
trimethylation (Lys36)
基因信息
human ... HIST1H3F(8968)
一般描述
Histones are highly conserved proteins that serve as the structural scaffold for the organization of nuclear DNA into chromatin. The four core histones, H2A, H2B, H3, and H4, assemble into an octamer (2 molecules of each). Subsequently, 146 base pairs of DNA are wrapped around the octamer, forming a nucleosome, the basic subunit of chromatin. Histones are modified post-translationally by the actions of enzymes in both the nucleus and cytoplasm. These modifications regulate DNA transcription, repair, recombination, and replication. The most commonly studied modifications are acetylation, phosphorylation, methylation, and ubiquitination. These modifications can alter local chromatin architecture, or recruit trans-acting factors that recognize specific histone modifications (the "histone code" hypothesis). The modifications occur predominantly on the N-terminal and C-terminal tails that extend beyond the nucleosome core particle. Methylation of histone H3 on Lys36 (H3K36me2/3) is tightly associated with actively transcribed genes, and this modification is found primarily within the coding region, suggesting H3K36 methylation is necessary for efficient RNA polymerase II elongation and processivity.
应用
Use Anti-trimethyl Histone H3 (Lys36) Antibody (Rabbit Polyclonal Antibody) validated in WB, DB, ICC, ChIP to detect trimethyl Histone H3 (Lys36) also known as H3K36me3, Histone H3 (tri methyl K36).
质量
Evaluated by Western Blot in Histone H3 recombinant proteins.
Western Blot Analysis: A 1:2,000 dilution of this antibody detected Histone H3 on 10 µg of Histone H3 recombinant proteins.
Western Blot Analysis: A 1:2,000 dilution of this antibody detected Histone H3 on 10 µg of Histone H3 recombinant proteins.
目标描述
~17 kDa observed
其他说明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Sadaf Harandi-Zadeh et al.
Antioxidants (Basel, Switzerland), 10(8) (2021-08-28)
Epigenetic aberrations are linked to sporadic breast cancer. Interestingly, certain dietary polyphenols with anti-cancer effects, such as pterostilbene (PTS), have been shown to regulate gene expression by altering epigenetic patterns. Our group has proposed the involvement of DNA methylation and
Veena Krishnamoorthy et al.
Journal of immunology (Baltimore, Md. : 1950), 194(7), 3191-3200 (2015-02-25)
The chemokine receptor CCR9 controls the immigration of multipotent hematopoietic progenitor cells into the thymus to sustain T cell development. Postimmigration, thymocytes downregulate CCR9 and migrate toward the subcapsular zone where they recombine their TCR β-chain and γ-chain gene loci.
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