ABE281
抗-EZH1抗体
from rabbit, purified by affinity chromatography
别名:
Histone-lysine N-methyltransferase EZH1, ENX-2, Enhancer of zeste homolog 1
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
immunohistochemistry
western blot
western blot
Species reactivity:
human, mouse
Citations:
6
Technique(s):
immunohistochemistry: suitable
western blot: suitable
western blot: suitable
Uniprot accession no.:
产品名称
抗-EZH1抗体, from rabbit, purified by affinity chromatography
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
human, mouse
species reactivity (predicted by homology)
rat (based on 100% sequence homology), bovine (based on 100% sequence homology), rhesus macaque (based on 100% sequence homology)
technique(s)
immunohistochemistry: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... EZH1(2145)
Analysis Note
对照
小鼠胚胎干细胞裂解液
小鼠胚胎干细胞裂解液
通过蛋白质印迹在小鼠胚胎干细胞裂解液中进行评估。
蛋白质印迹分析：0.2 µg/mL的该抗体在10 µg小鼠胚胎干细胞裂解液中检测到EZH1。
蛋白质印迹分析：0.2 µg/mL的该抗体在10 µg小鼠胚胎干细胞裂解液中检测到EZH1。
Application
使用经验证可用于IHC&WB的该抗-EZH1抗体检测EZH1蛋白。
免疫组化分析：一个代表性批次的1：1,000稀释液在人肺和肾脏组织中检测到EZH1。
研究子类别
组蛋白修饰蛋白
组蛋白修饰蛋白
研究类别
表观遗传学&核功能
表观遗传学&核功能
Biochem/physiol Actions
其他同源性：猪（94%序列同源性）。
该抗体可能识别 EZH1的所有亚型。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
多梳蛋白家族复合物负责哺乳动物和昆虫中数百个基因的调控。这些蛋白质负责染色质的组装和包装，并诱导组蛋白H3甲基化。EZH1 是PRC2/EED-EZH1 复合物的催化亚基。该复合物使组蛋白H3的Lys-27 甲基化，从而导致受影响靶基因的转录抑制。EZH1是胚胎干细胞衍生和自我更新所必需的，这说明它涉及胚胎干细胞的维持。
观测分子量〜85 kDa。Uniprot描述了EZH1的5种亚型。该抗体可能识别所有亚型。亚型A分子量为 85,271道尔顿。亚型B分子量为 86,025道尔顿。亚型C分子量为 80,699道尔顿。亚型D分子量为 76,952道尔顿。亚型E分子量为 68,961道尔顿。（Margueron, 2008）。
Immunogen
对应于人EZH1的KLH偶联线性肽。
Other Notes
替代：04-1047
浓度：请参考批次特异性浓缩物的检验报告。
Physical form
亲和纯化
纯化的兔多克隆抗体，溶于含有0.1 M Tris-甘氨酸（pH 7.4）、150 mM NaCl和0.05％叠氮化钠的缓冲液中。
Preparation Note
自收到之日起，在2-8°C条件下可稳定保存1年。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Sebastian C B Bremer et al.
Digestion, 102(2), 227-235 (2019-11-07)
Colorectal cancer (CRC) is the leading gastrointestinal malignancy. The development from premalignant intraepithelial lesions leading to invasive cancer is paradigmatic for the stepwise carcinogenesis of epithelial cancers, but the knowledge of the underlying mechanism of carcinogenesis and progression of CRC
Xue-Wei Wang et al.
The Journal of clinical investigation, 134(3) (2023-11-28)
Current treatments for neurodegenerative diseases and neural injuries face major challenges, primarily due to the diminished regenerative capacity of neurons in the mammalian CNS as they mature. Here, we investigated the role of Ezh2, a histone methyltransferase, in regulating mammalian
Sebastian C B Bremer et al.
Cancers, 14(12) (2022-06-25)
Tumor grading is a robust prognostic predictor in patients with neuroendocrine neoplasms (NEN) and guides therapy, especially in tumors with high proliferation. NEN can be separated into well-differentiated and poorly differentiated types. The more aggressive NEN have been further separated
Jing Liang et al.
British journal of pharmacology, 176(17), 3206-3219 (2019-06-05)
The increased proliferation and migration of vascular smooth muscle cells (VSMCs) after arterial injury contributes greatly to the pathogenesis of neointimal hyperplasia. As a major component of epigenetics, histone methylation plays an important role in several cardiovascular diseases. However, its
Jiajia Wang et al.
Science advances, 6(33), eaaz6477-eaaz6477 (2020-08-28)
Mutations in the polycomb repressive complex 2 (PRC2) can cause Weaver-like syndrome, wherein a patient cohort exhibits abnormal white matter; however, PRC2 functions in CNS myelination and regeneration remain elusive. We show here that H3K27me3, the PRC2 catalytic product, increases
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