ABC459
抗-NOX4抗体
from rabbit
别名:
NADPH oxidase 4, Kidney oxidase-1, KOX-1, Kidney superoxide-producing NADPH oxidase, Renal NAD(P)H-oxidase
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
immunocytochemistry
immunohistochemistry
immunohistochemistry
Species reactivity:
human, mouse
Citations:
5
Technique(s):
immunocytochemistry: suitable
immunohistochemistry: suitable
immunohistochemistry: suitable
Uniprot accession no.:
产品名称
抗-NOX4抗体, from rabbit
biological source
rabbit
conjugate
unconjugated
antibody form
purified antibody
antibody product type
primary antibodies
clone
polyclonal
species reactivity
human, mouse
species reactivity (predicted by homology)
rat (based on 100% sequence homology)
technique(s)
immunocytochemistry: suitable
immunohistochemistry: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... NOX4(50507)
Analysis Note
通过免疫组化在人肾组织中进行了评估。
免疫组化分析：该抗体的1:50稀释液在人肾组织中检测到NOX4 。
免疫组化分析：该抗体的1:50稀释液在人肾组织中检测到NOX4 。
Application
免疫组化分析：代表性批次的1：500和1：50稀释液分别在人肾脏和骨骼肌组织中检测到NOX4。
免疫组化分析: 代表性批次在小鼠肝组织中检测到NOX4（I. Fabregat, IDIBELL, Barcelona, Spain）。
免疫细胞化学分析：代表性批次在Hep3B细胞中检测到NOX4（Esther Bertran, IDIBELL, Barcelona, Spain）。
免疫组化分析：代表性批次在表达野生型Mdr2/p19或基因敲除Mdr2 ARF或基因敲除Stat3/Mdr2的小鼠肝组织中检测到NOX4（Sancho, P. et al. (2012).PLoS One.7(9):e45285.).
免疫组化分析: 代表性批次在小鼠肝组织中检测到NOX4（I. Fabregat, IDIBELL, Barcelona, Spain）。
免疫细胞化学分析：代表性批次在Hep3B细胞中检测到NOX4（Esther Bertran, IDIBELL, Barcelona, Spain）。
免疫组化分析：代表性批次在表达野生型Mdr2/p19或基因敲除Mdr2 ARF或基因敲除Stat3/Mdr2的小鼠肝组织中检测到NOX4（Sancho, P. et al. (2012).PLoS One.7(9):e45285.).
抗NOX4抗体是一种高度特异性的兔多克隆抗体，其靶向NADPH氧化酶（phox）&已在IHC &ICC中进行了测试。
研究子类别
凋亡-附加
凋亡-附加
研究类别
细胞凋亡 & 癌症
细胞凋亡 & 癌症
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
NOX4（NADPH氧化酶4）是一种吞噬细胞型氧化酶，类似于负责在嗜中性粒细胞中产生大量活性氧（ROS）并产生抗菌活性的氧化酶，并已被假定在肾脏中作为氧传感器调节肾皮质中促红细胞生成素的合成。
计算分子量为67 kDa
Immunogen
线性肽对应于人NOX4的C末端。
Other Notes
浓度：请参考批次特异性浓缩物的分析证书。
Physical form
在含 0.1 M Tris-甘氨酸（pH 7.4），150 mM NaCl 和 0.05％ 叠氮化钠的缓冲液中的纯化的兔多克隆抗体。
形式：纯化
纯化的蛋白 A
Preparation Note
自发运之日起，在 2-8°C 条件下可稳定保存1年
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Yung-Chih Chen et al.
Journal of the American Heart Association, 11(1), e022761-e022761 (2022-01-01)
Background Diabetes is known to accelerate atherosclerosis and increase plaque instability. However, there has been a lack of suitable animal models to study the effect of diabetes on plaque instability. We hypothesized that the tandem stenosis mouse model, which reflects
Joaquim Moreno-Càceres et al.
Cell death & disease, 8(10), e3098-e3098 (2017-10-13)
Hepatocellular carcinoma (HCC) is a heterogeneous tumour associated with poor prognostic outcome. Caveolin-1 (CAV1), a membrane protein involved in the formation of caveolae, is frequently overexpressed in HCC. Transforming growth factor-beta (TGF-β) is a pleiotropic cytokine having a dual role
Jin-Ran Chen et al.
JBMR plus, 4(8), e10376-e10376 (2020-08-18)
Estrogen deficiency and aging play critical roles in the pathophysiology of bone as a result of increased oxidative stress. It has been suggested that prevention of NADPH oxidase- (Nox-) dependent accumulation of ROS may be an approach to potentially minimize
Becky A Diebold et al.
Methods in molecular biology (Clifton, N.J.), 1982, 191-229 (2019-06-07)
The identification of NADPH oxidase (NOX) isoforms in tissues is essential for interpreting experiments and for next step decisions regarding cell lines, animal models, and targeted drug design. Two basic methods, immunoblotting and reverse transcriptase-quantitative polymerase chain reaction (RT-qPCR), are
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