ABC299
抗-FFAR2抗体/GPR43
from rabbit, purified by affinity chromatography
别名:
Free fatty acid receptor 2, G-protein coupled receptor 43, FFAR2/GPR43
产品名称
抗-FFAR2抗体/GPR43, from rabbit, purified by affinity chromatography
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
rat
species reactivity (predicted by homology)
human (based on 100% sequence homology), mouse
technique(s)
immunohistochemistry: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... FFAR2(2867)
Analysis Note
通过蛋白质印迹对CHEM-1细胞裂解液进行了评估。
蛋白质印迹分析：1.0 µg/mL该抗体在 10 µg CHEM-1细胞裂解液中检测到FFAR2/GPR43。
蛋白质印迹分析：1.0 µg/mL该抗体在 10 µg CHEM-1细胞裂解液中检测到FFAR2/GPR43。
Application
研究子类别
凋亡-附加
凋亡-附加
研究类别
细胞凋亡 & 癌症
细胞凋亡 & 癌症
蛋白印迹分析: 1.0 µg/mL代表性批次在10 µg RAW264.7细胞裂解物中检测到FFAR2/GPR43。
免疫组化分析：代表性批次的1：50稀释液在小鼠肾脏和小鼠肝脏组织中检测到FFAR2/GPR43。
免疫组化分析：代表性批次的1：50稀释液在小鼠肾脏和小鼠肝脏组织中检测到FFAR2/GPR43。
该抗FFAR2抗体/GPR43经过验证可用在蛋白质印迹和免疫组化中检测FFAR2/GPR43。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
游离脂肪酸受体2（FFAR2），也称为G蛋白偶联受体43（GPR43），充当短链脂肪酸的细胞膜受体，最终通过腺苷酸环化酶途径刺激G蛋白偶联的抑制（Gi）信号。发现FFAR2/GPR43主要在小肠固有层的白细胞中表达，但在肠的脾细胞，脂肪组织和肠内分泌细胞中也可以发现一些表达。有趣的是，因为FFAR2/GPR43可以感知短链脂肪酸，而短链脂肪酸通常是肠道菌群的关键代谢产物，所以它可以作为生物传感器来调节调节性T细胞的活性以及结肠炎等疾病的免疫反应。
观察值〜47 kDa。该蛋白的计算分子量为37 kDa，但由于高糖基化，可以在〜47 kDa处观察到。某些裂解液可能会出现未表征的条带。
Immunogen
GST标记的重组蛋白，对应于人FFAR2/GPR43的胞质域。
表位：细胞质结构域
Other Notes
浓度：请参考特定批次的数据表。
Physical form
亲和纯化
在含 0.1 M Tris-甘氨酸（pH 7.4），150 mM NaCl 和 0.05％ 叠氮化钠的缓冲液中的纯化的兔多克隆抗体。
Preparation Note
自收到之日起，在 2-8°C 条件下可稳定保存1年
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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