一般描述
ULK1或自噬相关蛋白1同源物（ATG1）是丝氨酸/苏氨酸蛋白激酶。它是一种普遍表达的蛋白，在大脑，骨骼肌和心脏中非常丰富。它参与mTOR受体的信号通路，导致营养缺乏细胞中自噬的调节。mTOR可以作为ULK1/FIP200/Atg13的复合物与ULK1相互作用。ULK1可能在神经元发育中起重要作用：通过靶向断裂ULK1s的激酶结构域来消除ULK1′s的酶活性，可能通过阻断ULK1介导的神经营养因子的运输来阻止发育中的小鼠大脑中神经元的生长。
免疫原
KLH偶联线性肽，对应于Ser1177磷酸化的人ULK1的C末端附近区域。
应用
抗磷酸化ULK1抗体（Ser777）是一种高度特异性的兔多克隆抗体，靶向自噬相关蛋白，&已在蛋白质印迹&肽抑制分析中测试。
通过蛋白质印迹/肽抑制分析在A431细胞裂解液中进行了评估。
蛋白质印迹/肽抑制分析：2 µg/mL的该抗体在10 µg A431细胞裂解物中检测到磷酸化ULK1（Ser777）。
蛋白质印迹/肽抑制分析：2 µg/mL的该抗体在10 µg A431细胞裂解物中检测到磷酸化ULK1（Ser777）。
质量
通过蛋白质印迹在A431细胞裂解物中进行了评估。
蛋白质印迹分析：2 µg/mL的该抗体在10 µg A431细胞裂解物中检测到磷酸化ULK1（Ser777）。
蛋白质印迹分析：2 µg/mL的该抗体在10 µg A431细胞裂解物中检测到磷酸化ULK1（Ser777）。
目标描述
观察值〜120 kDa
其他说明
浓度：请参考批次特异性浓缩物的检验报告。
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WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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