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一般描述
Cystatin-C is a cysteine protease inhibitor in mammals, which is essential in protein degradation and keeping an equilibrium between inhibitors and proteases. It is thought to be a better marker for renal dysfunction and potential kidney injury than creatinine. Recently, Cystatin-C has been implicated in primary hypertension and may be a novel marker in patients. Cystatin-C has also been implicated in oxidative stress-induced apoptosis of CNS neurons and has been shown to inhibit amyloid-beta deposition in Alzheimer′s disease models.
免疫原
KLH-conjugated linear peptide corresponding to human Cystatin-C.
应用
Anti-Cystatin-C Antibody detects level of Cystatin-C & has been published & validated for use in WB, IH(P).
Immunohistochemistry (paraffin) Analysis: A 1:1000 dilution of a previous lot detected Cystatin-C in purkinje cells of normal rat cerebellum, neurons of normal rat frontal lobe, and neurons in normal rat midbrain.
Research Category
Apoptosis & Cancer
Apoptosis & Cancer
Research Sub Category
Apoptosis - Additional
Neurodegenerative Diseases
Apoptosis - Additional
Neurodegenerative Diseases
质量
Evaluated by Western Blot in human kidney tissue lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected Cystatin-C in 10 µg of human kidney tissue lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected Cystatin-C in 10 µg of human kidney tissue lysate.
目标描述
~14 kDa observed.
An uncharacterized band may appear at ~62 kDa in some lysates.
An uncharacterized band may appear at ~62 kDa in some lysates.
外形
Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
储存及稳定性
Stable for 1 year at 2-8°C from date of receipt.
分析说明
Control
Human kidney tissue lysate
Human kidney tissue lysate
其他说明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存分类代码
12 - Non Combustible Liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Aintzane Urbizu et al.
Neuropathology and applied neurobiology, 41(4), 507-519 (2014-03-13)
As cystatin C (CysC) is involved in some forms of neurodegeneration, we investigated the possible relationship between CysC and multiple system atrophy (MSA), including its parkinsonian (MSAp) and cerebellar (MSAc) phenotypes. Cystatin C gene (CST3) haplotypes were determined by PCR
David Pires et al.
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Ayers, JI; Xu, G; Pletnikova, O; Troncoso, JC; Hart, PJ; Borchelt, DR
Acta Neuropathologica Communications null
Neus Barranco et al.
Translational neurodegeneration, 10(1), 37-37 (2021-09-28)
New fluid biomarkers for Alzheimer's disease (AD) that reveal synaptic and neural network dysfunctions are needed for clinical practice and therapeutic trial design. Dense core vesicle (DCV) cargos are promising cerebrospinal fluid (CSF) indicators of synaptic failure in AD patients.
April Nettesheim et al.
Journal of clinical medicine, 10(1) (2021-01-01)
Extracellular matrix (ECM) deposition in the trabecular meshwork (TM) is one of the hallmarks of glaucoma, a group of human diseases and leading cause of permanent blindness. The molecular mechanisms underlying ECM deposition in the glaucomatous TM are not known
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