产品名称
亨廷顿相互作用蛋白1相关蛋白（HIP1R）抗体, Chemicon®, from rabbit
biological source
rabbit
conjugate
unconjugated
antibody form
purified antibody
antibody product type
primary antibodies
clone
polyclonal
species reactivity
mouse, rat, human
manufacturer/tradename
Chemicon®
technique(s)
immunocytochemistry: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... HIP1R(9026)
Application
可使用这种亨廷顿相互作用蛋白1相关蛋白（HIP1R）抗体检测亨廷顿相互作用蛋白1相关蛋白（HIP1L），该抗体经验证可用于WB & IC。
研究子类别
神经退行性疾病
突触&突触生物学
神经退行性疾病
突触&突触生物学
研究类别
神经科学
神经科学
蛋白质印迹：该抗体的1:500-1:2,000稀释液在10 µg大鼠脑提取物和小鼠脑核后上清液中检测到亨廷顿相互作用蛋白1相关蛋白（HIP1R）。该抗体的1:500-1:2,000稀释液在10 µg大鼠脑提取物和小鼠脑核后上清液中检测到亨廷顿相互作用蛋白1相关蛋白（HIP1R）。
免疫细胞化学：先前批次的抗体已被独立实验室用于人细胞的IC。(Poupon, V., et al. (2008).PNAS.105(1): 168-173.)
最佳工作稀释度必须由最终用户进行确定。
免疫细胞化学：先前批次的抗体已被独立实验室用于人细胞的IC。(Poupon, V., et al. (2008).PNAS.105(1): 168-173.)
最佳工作稀释度必须由最终用户进行确定。
Biochem/physiol Actions
亨廷顿相互作用蛋白1相关蛋白（HIP1R）。 通过蛋白质印迹法，该抗体可识别胚胎大鼠脑中P2微粒体部分~116 kDa 的条带。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
~116 kDa
亨廷顿相互作用蛋白1相关蛋白（HIP1R）是一种肌动蛋白结合蛋白，被认为是网格蛋白包被的小窝和囊泡的一部分，可聚合肌动蛋白。HIP1R对于正常的肌动蛋白组织和内吞作用至关重要。HIP1R具有epsin N端同源结构域，使其能够结合3-磷酸化肌醇脂质，从而使HIP1R能够作为酪氨酸激酶稳定受体发挥作用，并在细胞整体生长和存活中发挥作用。
Immunogen
合成肽
Physical form
形式：纯化
液体
Preparation Note
自收到之日起，在 -20°C 以未稀释的等分试样可保存 6 个月。应避免反复冻/融循环。
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
10 - Combustible liquids
wgk
WGK 1
M A Rice et al.
Oncogene, 35(36), 4752-4761 (2016-02-24)
Deregulation of microRNAs (miRs) contributes to progression and metastasis of prostate and other cancers. miR-23b and -27b, encoded in the same miR cluster (miR-23b/-27b), are downregulated in human metastatic prostate cancer compared with primary tumors and benign tissue. Expression of
Qian Yang et al.
Frontiers in molecular neuroscience, 11, 447-447 (2018-12-24)
Huntington-interacting protein 1-related protein (HIP1R) was identified on the basis of its structural homology with HIP1. Based on its domain structure, HIP1R is a putative endocytosis-related protein. Our previous study had shown that knockdown of HIP1R induces a dramatic decrease
Sophia R Majeed et al.
Nature communications, 5, 3891-3891 (2014-05-24)
The clathrin light chain (CLC) subunits participate in several membrane traffic pathways involving both clathrin and actin, through binding the actin-organizing huntingtin-interacting proteins (Hip). However, CLCs are dispensable for clathrin-mediated endocytosis of many cargoes. Here we observe that CLC depletion
Lin Peng et al.
Frontiers in molecular neuroscience, 10, 186-186 (2017-07-01)
Huntingtin-interacting protein 1-related (HIP1R) protein is considered to be an endocytic adaptor protein like the other two members of the Sla2 family, Sla2p and HIP1. They all contain homology domains responsible for the binding of clathrin, inositol lipids and F-actin.
Markus Mukenhirn et al.
Cells, 10(2) (2021-03-07)
One of the most fundamental processes of the cell is the uptake of molecules from the surrounding environment. Clathrin-mediated endocytosis (CME) is the best-described uptake pathway and regulates nutrient uptake, protein and lipid turnover at the plasma membrane (PM), cell
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