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Merck
CN

AB9076

IP3受体3抗体

serum, Chemicon®

别名:

Inositol 1,4,5-Trisphosphate Receptor 3

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关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
immunocytochemistry
immunohistochemistry
western blot
Species reactivity:
mouse, rat, human
Citations:
16
Technique(s):
immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable
Uniprot accession no.:
Q14573

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产品名称

IP3受体3抗体, serum, Chemicon®

biological source

rabbit

conjugate

unconjugated

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

mouse, rat, human

manufacturer/tradename

Chemicon®

technique(s)

immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable

NCBI accession no.

NM_002224.2

UniProt accession no.

Q14573

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... ITPR3(3710)
mouse ... Itpr3(16440)
rat ... Itpr3(25679)

相关类别

Analysis Note

对照
蛋白质印迹 = 成年小鼠胰腺。

IHC = 成年小鼠肝细胞（成年小鼠小脑颗粒细胞为阴性）。

Application

IP3受体3抗体可检测IP3受体水平 & 已发表 & 经验证可用于IC、IH & WB。
研究子类别
脂质信号转导
研究类别
信号传导
蛋白质印迹：使用ECL为1：1,000。该抗体可与250 kDa的IP3受体3蛋白反应。建议的封闭缓冲液为10%正常山羊血清（或与你的二抗相同的宿主），1%BSA的含0.05%吐温20的0.1 M PBS。建议的稀释缓冲液为1%正常山羊血清（或与你的二抗相同的宿主），1%BSA的含0.05%吐温20的0.1 M PBS。优选的凝胶百分比是4-12%梯度凝胶。

免疫细胞化学：1：1,000

免疫组化：使用荧光标记的二抗在2-8°C下以1：1,000过夜。建议的固定剂是0.1 M PBS中的4%多聚甲醛（一小时）。建议的透化方法是0.05%Triton X-100稀释缓冲液。建议的封闭缓冲液为10%正常山羊血清（或与你的二抗相同的宿主）和1%BSA的0.1 M PBS。建议的稀释缓冲液为1%正常山羊血清（或与你的二抗相同的宿主）和1%BSA的0.1 M PBS。

最佳工作稀释度必须由最终用户进行确定。

Biochem/physiol Actions

IP3受体3。

Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

Immunogen

来自大鼠IP3受体3 C端的合成肽。

Physical form

兔血清。 液体。

Preparation Note

自收到之日起，在 -20°C 以未稀释的等分试样可保存 6 个月。应避免反复冻/融循环。

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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存储类别

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Alexander Becker et al.
Diabetes, 70(11), 2532-2544 (2021-08-25)
Voltage-gated Ca2+ (Cav) channels consist of a pore-forming Cavα1 subunit and auxiliary Cavα2-δ and Cavβ subunits. In fibroblasts, Cavβ3, independent of its role as a Cav subunit, reduces the sensitivity to low concentrations of inositol-1,4,5-trisphosphate (IP3). Similarly, Cavβ3 could affect
Laura Marongiu et al.
Science signaling, 14(676) (2021-04-01)
Innate immune responses to Gram-negative bacteria depend on the recognition of lipopolysaccharide (LPS) by a receptor complex that includes CD14 and TLR4. In dendritic cells (DCs), CD14 enhances the activation not only of TLR4 but also that of the NFAT
Sofia Håglin et al.
Bio-protocol, 11(8), e3983-e3983 (2021-06-15)
Odor-detecting olfactory sensory neurons residing in the nasal olfactory epithelium (OE) are the only neurons in direct contact with the external environment. As a result, these neurons are subjected to chemical, physical, and infectious insults, which may be the underlying
S Kaja et al.
Neuroscience, 175, 281-291 (2010-11-16)
Dysregulation of Ca(2+) signaling following oxidative stress is an important pathophysiological mechanism of many chronic neurodegenerative disorders, including Alzheimer's disease, age-related macular degeneration, glaucomatous and diabetic retinopathies. However, the underlying mechanisms of disturbed intracellular Ca(2+) signaling remain largely unknown. We
Pancreatic protease activation by alcohol metabolite depends on Ca2+ release via acid store IP3 receptors.
Gerasimenko, JV; Lur, G; Sherwood, MW; Ebisui, E; Tepikin, AV; Mikoshiba, K; Gerasimenko et al.
Proceedings of the National Academy of Sciences of the USA null
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