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Merck
CN

AB6030

整合素α10（ITGA10）抗体

from rabbit, purified by affinity chromatography

别名:

Integrin, alpha 10, integrin alpha-10

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关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702

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产品名称

整合素α10（ITGA10）抗体, from rabbit, purified by affinity chromatography

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

rhesus macaque, primate, human

species reactivity (predicted by homology)

canine (based on 100% sequence homology), chimpanzee (based on 100% sequence homology), rhesus monkey (based on 100% sequence homology), pig (based on 100% sequence homology)

technique(s)

western blot: suitable

NCBI accession no.

NP_003628

UniProt accession no.

O75578

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... ITGA10(8515)

相关类别

Analysis Note

对照
SW-1353细胞裂解液
通过蛋白质印迹法对SW-1353细胞裂解液进行了评估。

蛋白质印迹分析：0.5 µg/mL的该抗体在10 µg SW-1353细胞裂解液中检测到整合素α10。

Application

可使用这种经验证可用于WB的整合素α10（ITGA10）抗体检测整合素α10（ITGA10）。
研究子类别
整合素

粘附（CAM）
研究类别
细胞结构

Biochem/physiol Actions

其他同源性：大鼠（具有93%的序列同源性）。
该抗体可识别整合素α10的胞外结构域。

Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

General description

整合素是跨膜蛋白，参与细胞间和细胞与胞外基质（ECM）的粘附。整合素发挥多种作用，包括细胞迁移、发育、伤口愈合、分化和凋亡。整合素α10亚基（ITGA10）和整合素β1被认为是主要在软骨细胞和软骨组织中表达的新型II型胶原受体的重要组成部分。
观察值〜127 kDa

Immunogen

KLH偶联线性肽，对应于人整合素α10的胞外域。
表位：胞外结构用

Other Notes

浓度：请参考批次特异性浓缩物的检验报告。

Physical form

亲和纯化
纯化的兔多克隆抗体，溶于含有0.1 M Tris-甘氨酸（pH 7.4）、150 mM NaCl和0.05％叠氮化钠的缓冲液中。

Preparation Note

自收到之日起，在2-8°C条件下可稳定保存1年。

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存储类别

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Yibo Song et al.
Regenerative therapy, 21, 342-350 (2022-09-27)
To probe the impacts and biological roles of miR-4739/ITGA10 on the proliferation, differentiation and apoptosis of osteoblasts. Bioinformatics analysis was conducted to screen the key genes in osteoporosis. The upstream miRNAs of ITGA10 were predicted by TargetScan. KEGG pathway enrichment
Yen-Lin Huang et al.
eLife, 9 (2020-10-08)
The extracellular matrix (ECM) plays critical roles in tumor progression and metastasis. However, the contribution of ECM proteins to early metastatic onset in the peritoneal cavity remains unexplored. Here, we suggest a new route of metastasis through the interaction of
B E Engel et al.
Cell death & disease, 4, e938-e938 (2013-11-30)
pRb is known as a classic cell cycle regulator whose inactivation is an important initiator of tumorigenesis. However, more recently, it has also been linked to tumor progression. This study defines a role for pRb as a suppressor of the
Sarah M Pearsall et al.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 18(10), 1362-1385 (2023-07-17)
Vasculogenic mimicry (VM), the process of tumor cell transdifferentiation to endow endothelial-like characteristics supporting de novo vessel formation, is associated with poor prognosis in several tumor types, including SCLC. In genetically engineered mouse models (GEMMs) of SCLC, NOTCH, and MYC
Tobias G Schips et al.
Nature communications, 10(1), 76-76 (2019-01-10)
Thrombospondins (Thbs) are a family of five secreted matricellular glycoproteins in vertebrates that broadly affect cell-matrix interaction. While Thbs4 is known to protect striated muscle from disease by enhancing sarcolemmal stability through increased integrin and dystroglycan attachment complexes, here we

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