产品名称
Anti-Amyloid Precursor Protein Antibody, Domain 770, Chemicon®, from rabbit
technique(s)
immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
biological source
rabbit
antibody form
affinity purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
human, monkey
manufacturer/tradename
Chemicon®
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... APP(351)
Immunogen
Synthetic peptide corresponding to the OX2 domain of APP770.
Epitope: OX2 Domain 770
Physical form
Affinity purified immunoglobulin. Liquid in TRIS-buffered saline with 0.01% sodium azide.
Application
Anti-Amyloid Precursor Protein Antibody, Domain 770 detects level of Amyloid Precursor Protein & has been published & validated for use in IP, WB, IC, IH.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Neurodegenerative Diseases
Neurodegenerative Diseases
Western Blot
Immunohistochemistry on cold methanol fixed tissues.
Immunocytochemistry
Immunoprecipitation
Optimal working dilutions must be determined by the end user.
Immunohistochemistry on cold methanol fixed tissues.
Immunocytochemistry
Immunoprecipitation
Optimal working dilutions must be determined by the end user.
Biochem/physiol Actions
Amyloid precursor protein (APP), domain 770, but not APP751 or APP695.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Preparation Note
Maintain at 2-8°C in undiluted aliquots for up to 6 months.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Hitomi Komura et al.
iScience, 13, 452-477 (2019-03-05)
We identified ∼30-mer amyloid-β protein (Aβ) assemblies, termed amylospheroids, from brains of patients with Alzheimer disease (AD) as toxic entities responsible for neurodegeneration and showed that Na+,K+-ATPase α3 (NAKα3) is the sole target of amylospheroid-mediated neurodegeneration. However, it remains unclear
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