生物来源
rabbit
质量水平
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
纯化方式
affinity chromatography
种属反应性
mouse, human, rat
制造商/商品名称
Chemicon®
技术
western blot: suitable
NCBI登记号
UniProt登记号
运输
wet ice
靶向翻译后修饰
unmodified
基因信息
mouse ... Rtn4(68585)
一般描述
This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified
特异性
Cat. # AB5888 is specific to NOGO A. It does not recognize NOGO B or NOGO C.
Reactivity with other species has not been tested.
应用
Anti-NOGO A Antibody detects level of NOGO A & has been published & validated for use in WB.
质量
Routinely tested on mouse brain lysate
目标描述
Theoretical MW is approx. 126 kDa however literature reports observed molecular weight to be 205 kDa to 220 kDa
法律信息
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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储存分类代码
10 - Combustible liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Feng Tan et al.
Experimental and therapeutic medicine, 16(6), 4943-4950 (2018-12-14)
Electroacupuncture (EA) may stimulate neurogenesis in animal models of ischemic stroke; however, the associated mechanisms are not clear. The present study aimed to evaluate the neurogenesis efficacy of EA on ischemic stroke and the underlying associated mechanisms. A model of
Giuseppe Vaccaro et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 42(20), 4087-4100 (2022-04-20)
Nogo-66 receptors (NgR1-3) are glycosylphosphatidyl inositol-linked proteins that belong to the leucine-rich repeat superfamily. Through binding to myelin-associated inhibitors, NgRs contribute to the inhibition of axonal regeneration after spinal cord injury. Their role in limiting synaptic plasticity and axonal outgrowth
María Nazareth González-Alvarado et al.
Glia, 70(3), 522-535 (2021-11-18)
Recently, oligodendrocytes (Ol) have been attributed potential immunomodulatory effects. Yet, the exact mode of interaction with pathogenic CNS infiltrating lymphocytes remains unclear. Here, we attempt to dissect mechanisms of Ol modulation during neuroinflammation and characterize the interaction of Ol with
Theresa Scholl et al.
Journal of neuropathology and experimental neurology, 80(3), 274-282 (2021-02-01)
Complex cortical malformations (CCMs), such as hemimegalencephaly and polymicrogyria, are associated with drug-resistant epilepsy and developmental impairment. They share certain neuropathological characteristics including mammalian target of rapamycin (mTOR) activation and an atypical number of white matter neurons. To get a
Ryan L O'Hare Doig et al.
BMC neuroscience, 18(1), 62-62 (2017-08-16)
Following partial injury to the central nervous system, cells beyond the initial injury site undergo secondary degeneration, exacerbating loss of neurons, compact myelin and function. Changes in Ca2+ flux are associated with metabolic and structural changes, but it is not
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