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Merck
CN

AB5864

抗髓磷脂碱性蛋白抗体

CHEMICON®, rabbit polyclonal

别名:

MBP

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关于此项目

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Clone:
polyclonal
Species reactivity:
human, rat
Application:
immunohistochemistry
Technique(s):
immunohistochemistry: suitable
Citations:
75
Uniprot accession no.:
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产品名称

抗髓磷脂碱性蛋白抗体, serum, Chemicon®

biological source

rabbit

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human, rat

manufacturer/tradename

Chemicon®

technique(s)

immunohistochemistry: suitable

UniProt accession no.

shipped in

dry ice

target post-translational modification

unmodified

Quality Level

Gene Information

human ... MBP(4155)
rat ... Mbp(24547)

Analysis Note

对照
脑组织

Application

免疫组化:1:2,000。免疫染色脱髓鞘区域异常出现的少突胶质细胞过程和细胞体的髓鞘碱性蛋白。当在受损的脊髓和受损的坐骨神经中进行测试时,该抗体仅识别髓鞘变性区域。它还会染色多系统萎缩大脑中的离散白质。

最佳工作稀释度必须由最终用户确定。
抗髓鞘碱性蛋白抗体是用于IH的抗髓鞘碱性蛋白的抗体。
研究子类别
神经元& 胶质标记

神经退行性疾病
研究类别
神经科学

Biochem/physiol Actions

识别脱髓鞘神经组织中的髓鞘碱性蛋白。病变大鼠脊髓的免疫组化分析显示该抗血清的高水平特异性。

Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

Immunogen

对应豚鼠蛋白69-86位氨基酸的合成肽。免疫原对应于“降解"的髓磷脂碱性蛋白: YGSLPQKSQRSQDENPVV

Other Notes

浓度:请参考批次特异性浓缩物的分析证书。

Physical form

兔血清。 冻干,没有防腐剂。用50 μL无菌蒸馏水复溶。离心以除去所有残留物。
未纯化

Preparation Note

自收到之日起,在 -20-70° 以未稀释的等分试样可保存 12 个月。应避免反复冻/融循环。可以添加甘油(1:1)以获得额外的稳定性。

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


分析证书(COA)

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Role of myelin auto-antigens in pain: a female connection.
Veronica I Shubayev et al.
Neural regeneration research, 11(6), 890-891 (2016-08-03)
Brian D Clark et al.
Journal of neurotrauma, 20(7), 681-695 (2003-08-12)
Anatomical and physiological changes were evaluated in the median nerves of rats trained to perform repetitive reaching. Motor degradation was evident after 4 weeks. ED1-immunoreactive macrophages were seen in the transcarpal region of the median nerve of both forelimbs by
Maria L Allende et al.
Journal of lipid research, 59(3), 550-563 (2018-01-24)
Sandhoff disease, one of the GM2 gangliosidoses, is a lysosomal storage disorder characterized by the absence of β-hexosaminidase A and B activity and the concomitant lysosomal accumulation of its substrate, GM2 ganglioside. It features catastrophic neurodegeneration and death in early
James Rice et al.
Acta neuropathologica communications, 7(1), 173-173 (2019-11-11)
Adolescent binge drinking represents a major public health challenge and can lead to persistent neurological and mental conditions, but the underlying pathogenic mechanisms remain poorly understood. Using a mouse model of adolescent binge ethanol treatment (ABET), we found that this
Yun Ju C Song et al.
The American journal of pathology, 171(4), 1291-1303 (2007-09-08)
p25alpha is an oligodendroglial protein that can induce aggregation of alpha-synuclein and accumulates in oligodendroglial cell bodies containing fibrillized alpha-synuclein in the neurodegenerative disease multiple system atrophy (MSA). We demonstrate biochemically that p25alpha is a constituent of myelin and a

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