产品名称
抗淀粉样蛋白抗体,β1-40/42, serum, Chemicon®
biological source
rabbit
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
human, mouse
manufacturer/tradename
Chemicon®
technique(s)
ELISA: suitable
immunohistochemistry: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... APP(351)
Analysis Note
对照
阿尔茨海默′病的脑组织,小鼠大脑的全组织提取物。
阿尔茨海默′病的脑组织,小鼠大脑的全组织提取物。
Application
抗淀粉样蛋白抗体,β1-40/42是用于ELISA,IH&WB的针对淀粉样蛋白的抗体。
研究子类别
神经退行性疾病
神经退行性疾病
研究类别
神经科学
神经科学
蛋白质印迹:1:1,000-1:5,000(化学发光技术)
免疫组化:使用福尔马林或多聚甲醛固定的阿尔茨海默′脑组织为1:100。
ELISA:1:10,000-1:100,000(50-100 ng免疫原肽/孔)。
免疫原控制肽的目录号为AG365。
最佳工作稀释度必须由最终用户进行确定。
免疫组化:使用福尔马林或多聚甲醛固定的阿尔茨海默′脑组织为1:100。
ELISA:1:10,000-1:100,000(50-100 ng免疫原肽/孔)。
免疫原控制肽的目录号为AG365。
最佳工作稀释度必须由最终用户进行确定。
Biochem/physiol Actions
识别β-淀粉样蛋白1-40/42。在阿尔茨海默′病(AD)中引起记忆和认知丧失的最重要和最初始的步骤之一是淀粉样蛋白前体蛋白(APP,21号染色体)的蛋白水解裂解,释放短的40、42、&43氨基酸肽(β淀粉样蛋白1-40、1-42和1-43)。β-淀粉样蛋白的聚合和随后的神经元沉积(淀粉样蛋白)导致参与记忆和认知的神经元变性。免疫原肽显示与β-淀粉样蛋白1-28和β-淀粉样蛋白12-28的同源性。没有观察到与CGRP的交叉反应性。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
Immunogen
一种与BSA偶联的合成β-淀粉样蛋白肽1-40。
Other Notes
替代品:AB5408
浓度:请参考批次特异性浓缩物的分析证书。
Physical form
兔血清。 液体和0.1%叠氮化钠。
未纯化
Preparation Note
自收到之日起在-20°C可稳定保存1年。避免反复冻融。为了最大程度地回收产品,在融化后和取下盖子之前,将原始样品瓶进行离心。
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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