推荐产品
生物来源
rabbit
质量水平
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
纯化方式
affinity chromatography
种属反应性
horse, human, mouse
种属反应性（根据同源性预测）
sheep (based on 100% sequence homology), canine (based on 100% sequence homology), rat (based on 100% sequence homology), equine (based on 100% sequence homology), bovine (based on 100% sequence homology)
技术
immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable
NCBI登记号
UniProt登记号
运输
wet ice
靶向翻译后修饰
unmodified
基因信息
human ... ISL1(3670)
一般描述
胰岛因子1（ISL-1）是一种转录因子，在朗格汉斯胰岛的胚胎发生中发挥重要作用。它在肾上腺髓质和背根神经节的神经元亚群、视网膜内核和神经节细胞层、松果体和大脑某些区域中表达。在小鼠胚胎中，缺乏这种基因就无法进行神经管运动神经元的分化。最近，它被确定为心脏祖细胞谱系的标志物，该谱系能够分化为所有3种主要心脏细胞类型：心肌细胞、平滑肌和内皮细胞谱系。
特异性
基于100%的序列同源性，预测会与最常见的脊椎动物物种反应。
该抗体可识别ISL-1。
免疫原
KLH偶联线性肽，对应于人ISL-1。
表位：ISL-1的内部区域。
应用
ISL-1抗体是一种检测ISL-1（又称ISL LIM同源盒1、ISL1转录因子LIM/同源结构域）的兔多克隆抗体 & 已通过WB & IHC验证。
免疫组化分析：先前批次的1:300稀释液在小鼠胰腺组织中检测到ISL-1。
质量
通过蛋白质印迹法对K562细胞裂解液进行了评估。
蛋白质印迹分析：0.5 µg/mL的该抗体在10 µg K562细胞裂解液中检测到ISL-1。
蛋白质印迹分析：0.5 µg/mL的该抗体在10 µg K562细胞裂解液中检测到ISL-1。
目标描述
~39 kDa
其他说明
浓度：请参考批次特异性浓缩物的检验报告。
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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Experimental neurology, 277, 171-177 (2016-01-10)
Among several genetic mutations known to cause amyotrophic lateral sclerosis (ALS), a hexanucleotide repeat expansion in the C9orf72 gene is the most common. In approximately 30% of C9orf72-ALS cases, 5-methylcytosine (5mC) levels within the C9orf72 promoter are increased, resulting in
Joseph A Bisson et al.
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Human motor neuron (MN) diseases encompass a spectrum of disorders. A critical barrier to dissecting disease mechanisms is the lack of appropriate human MN models. Here, we describe a scalable, suspension-based differentiation system to generate functional human MN diseases in
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Transplantation of motoneurons (MN) into the peripheral nerve to provide a source of neurons for muscle reinnervation, termed motoneuron integrated striated muscle (MISM), may provide the potential to restore functional muscle activity, when combined with computer-programmed functional electrical stimulation (FES).
Zane Zeier et al.
Experimental neurology, 271, 241-250 (2015-06-24)
A hexanucleotide repeat expansion residing within the C9ORF72 gene represents the most common known cause of amyotrophic lateral sclerosis (ALS) and places the disease among a growing family of repeat expansion disorders. The presence of RNA foci, repeat-associated translation products
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