AB4073
抗-法呢基抗体
Chemicon®, from rabbit
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Clone:
polyclonal
Technique(s):
ELISA: suitable
immunofluorescence: suitable
immunofluorescence: suitable
Application:
ELISA
immunofluorescence
immunofluorescence
Citations:
8
产品名称
抗-法呢基抗体, Chemicon®, from rabbit
biological source
rabbit
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
species reactivity (predicted by homology)
all
manufacturer/tradename
Chemicon®
technique(s)
ELISA: suitable
immunofluorescence: suitable
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
General description
蛋白异戊二烯化是一种翻译后修饰，影响约0.5%的细胞蛋白，对蛋白的生物活性至关重要。两种酶催化两个异戊二烯基与羧基末端半胱氨酸基的巯基的连接。被这些酶异戊二烯化的蛋白质在蛋白C-A1-A2-X的C末端具有独特的基序（C=半胱氨酸，A 1 &A2=脂肪族氨基酸）。参与该转移的两种酶是法呢基转移酶和香叶酰香叶酰转移酶。这些分别将15碳的法呢基或20碳的香叶酰香叶酰从异戊二烯焦磷酸盐转移至蛋白。含有这种C-A-A-X基序的蛋白质的例子是Ras小G蛋白家族的成员，核纤层蛋白和三聚体G蛋白的γ亚基。蛋白质的异戊二烯化对于蛋白质的膜结合以及蛋白质-蛋白质的各种相互作用是必需的，并且连接的异平基的性质会影响蛋白质的各种相互作用，例如G蛋白与受体之间的相互作用。
Immunogen
使用与KLH偶联的法呢基半胱氨酸开发的抗体。
Other Notes
浓度：请参考批次特异性浓缩物的分析证书。
Physical form
形式：纯化
纯化的免疫球蛋白。 磷酸盐缓冲盐水和0.08%叠氮化钠中的无菌液体。
Preparation Note
收到货后，在-20°C下以未稀释等分试样可保存长达12个月。 应避免反复冻/融循环。
Application
ELISA
免疫荧光
最佳工作稀释度必须由最终用户确定。
免疫荧光
最佳工作稀释度必须由最终用户确定。
抗法呢基抗体可检测法呢基的水平&已发表& 经验证可用于ELISA&IF。
研究子类别
MAP激酶
MAP激酶
研究类别
信号传导
信号传导
Biochem/physiol Actions
识别源自异戊烯化C-A-A-X序列的法呢基基序。也与香叶酰香叶酰基序发生交叉反应。也检测KLH。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Zurab Siprashvili et al.
Nature genetics, 48(1), 53-58 (2015-11-26)
Small nucleolar RNAs (snoRNAs) are conserved noncoding RNAs best studied as ribonucleoprotein (RNP) guides in RNA modification. To explore their role in cancer, we compared 5,473 tumor-normal genome pairs to identify snoRNAs with frequent copy number loss. The SNORD50A-SNORD50B snoRNA
Fei Liu et al.
Human molecular genetics, 24(16), 4648-4659 (2015-06-03)
Retinitis pigmentosa (RP) affects about 1.8 million individuals worldwide. X-linked retinitis pigmentosa (XLRP) is one of the most severe forms of RP. Nearly 85% of XLRP cases are caused by mutations in the X-linked retinitis pigmentosa 2 (RP2) and RPGR.
C Banfi et al.
Communications biology, 4(1), 1109-1109 (2021-09-23)
The research into the pathophysiology of atherosclerosis has considerably increased our understanding of the disease complexity, but still many questions remain unanswered, both mechanistically and pharmacologically. Here, we provided evidence that the pro-oxidant enzyme Prenylcysteine Oxidase 1 (PCYOX1), in the
Tsuyoshi Waku et al.
iScience, 24(10), 103180-103180 (2021-10-21)
Lipids, such as cholesterol and fatty acids, influence cell signaling, energy storage, and membrane formation. Cholesterol is biosynthesized through the mevalonate pathway, and aberrant metabolism causes metabolic diseases. The genetic association of a transcription factor NRF3 with obesity has been
Kazuhiro Shirozu et al.
Shock (Augusta, Ga.), 42(6), 570-577 (2014-07-22)
Acute liver failure (ALF) is a fatal syndrome associated with massive hepatocyte death. There is no cure for ALF except liver transplantation. Protein farnesylation is a lipid modification of cysteine residues that is catalyzed by farnesyltransferase (FTase) and has been
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