推荐产品
生物来源
rabbit
质量水平
抗体形式
affinity purified immunoglobulin
抗体产品类型
primary antibodies
克隆
polyclonal
种属反应性
human
制造商/商品名称
Chemicon®
技术
western blot: suitable
UniProt登记号
运输
wet ice
靶向翻译后修饰
unmodified
一般描述
凋亡受包含分子和蛋白酶的胱天蛋白酶家族的死亡结构域(DD)和/或胱天蛋白酶募集结构域(CARD)调节。 含有细胞死亡调节剂的CARD包括RAIDD,RICK,Bcl10,Apaf-1,ARC,胱天蛋白酶-2和胱天蛋白酶-9。 已经在人和小鼠中鉴别出含有蛋白的新型CARD结构域,并将其命名为ASC和TMS1。 ASC/TMS1的异位表达通过激活胱天蛋白酶-9诱导凋亡并抑制人乳腺癌细胞的存活。 ASC/TMS1的过表达诱导DNA断裂。 ASC/TMS1在多种人类和小鼠组织中表达。
特异性
通过蛋白质印迹检测对应于ASC/TMS1的25 kDa条带。
免疫原
对应于人ASC的aa 182-195(RESQSYLVEDLERS)的肽。
应用
研究子类别
凋亡-附加
凋亡-附加
研究类别
细胞凋亡 & 癌症
细胞凋亡 & 癌症
蛋白质印迹:1:500
HL60全细胞裂解液可作为阳性对照。
最佳工作稀释度必须由最终用户进行确定。
HL60全细胞裂解液可作为阳性对照。
最佳工作稀释度必须由最终用户进行确定。
该抗ASC抗体经过验证可用于WB检测ASC。
外形
亲和纯化的免疫球蛋白。 含0.02%叠氮化钠的PBS液体。
形式:纯化
储存及稳定性
在4°C下可保存长达6个月。
其他说明
浓度:请参考批次特异性浓缩物的分析证书。
法律信息
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
未找到合适的产品?
试试我们的产品选型工具.
储存分类代码
10 - Combustible liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Brain and behavior, 13(5), e2980-e2980 (2023-03-30)
Cognitive impairment is a critical complication of acute respiratory distress syndrome (ARDS). However, effective interventions are lacking. Growing evidence demonstrates that c-Jun N-terminal kinase (JNK)-mediated neuroinflammation is involved in the development of ARDS. Therefore, we hypothesized that the JNK pathway
The Journal of biological chemistry, 294(21), 8480-8489 (2019-04-04)
Among the repertoire of immunoregulatory proteins encoded by myxoma virus, M013 is a viral homologue of the viral pyrin domain-only protein (vPOP) family. In myeloid cells, M013 protein has been shown to inhibit both the inflammasome and NF-κB signaling pathways
Cell death & disease, 7(8), e2322-e2322 (2016-08-05)
Autophagosomes derived from tumor cells, also referred to as defective ribosomal products in blebs (DRibbles), have been previously shown to stimulate potent T-cell responses and mediate tumor regression when used as therapeutic cancer vaccines in multiple preclinical cancer models. In
Journal of Crohn's & colitis, 15(4), 647-664 (2020-10-07)
Crohn's disease [CD] is a chronic, relapsing and incurable inflammatory disorder. Micro RNAs [miRNAs], which modulate gene expression by binding to mRNAs, may make significant contributions to understanding the complex pathobiology and aetiology of CD. This study aimed to investigate
Evidence-based complementary and alternative medicine : eCAM, 2021, 1821220-1821220 (2021-10-05)
Acne vulgaris (AV) is a chronic skin disease involving inflammation of the pilosebaceous units. Propionibacterium acnes (P. acnes) hypercolonization is one pathogenic factor for AV. P. acnes that triggers interleukin-1β (IL-1β) by activating the pyrin domain-containing 3 protein (NLRP3) inflammasome
我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门