Anti-Bcl-xL Antibody, Phospho-specific

Bcl-XL is one of the anti-apoptotic members of the Bcl-2 family of apoptosis regulators and is overexpressed in many human cancers. Studies by Dr. Haldar and his associates suggest that microtubule damaging drugs like Taxol or 2-methoxyestradiol induce phosphorylation of Bcl-XL at serine 62 by kinases such as Jun and this allows those cells to die by apoptosis.

AB3116 is specific for the Bcl-xL phosphorylated on serine 62. It does not recognize the unphosphorylated form of the protein.

Epitope: Phospho-specific

Synthetic phosporylated peptide corresponding to a sequence encompassing serine 62 of human Bcl-xL conjugated to KLH.

Detect Bcl-xL using this Anti-Bcl-xL Antibody, Phospho-specific validated for use in WB.

Immunoblotting: Recommended dilution is 1:100

Optimal dilutions must be determined by end-user.

Research Category
Apoptosis & Cancer

Research Sub Category
BCL2 & Inhibition

Tumor Markers

Liquid rabbit serum containing no preservatives.

Maintain at -80°C for up to 12 months from date of receipt. Avoid repeated freeze/thaw cycles.

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