AB3096
抗促食欲素抗体，前体
Chemicon®, from rabbit
别名:
Anti-NRCLP1, Anti-OX, Anti-PPOX
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, IHC, WB
Citations:
18
biological source
rabbit
conjugate
unconjugated
antibody form
affinity purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
mouse, human, rat
manufacturer/tradename
Chemicon®
technique(s)
ELISA: suitable, immunohistochemistry: suitable, western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... PPOX(5498)
Immunogen
17肽（称为PPOXA11-A）定位在小鼠前体食欲素的C末端附近。
Application
抗食欲素抗体，前体是用于ELISA，IH&WB的针对食欲素的抗体。
研究子类别
代谢的CNS控制
昼夜节律性&睡眠
代谢的CNS控制
昼夜节律性&睡眠
研究类别
神经科学
神经科学
蛋白质印迹：使用化学发光技术为1-10μg/mL
ELISA：1：10,000 - 100,000
免疫组化：2-20 μg/mL。
最佳工作稀释度必须由最终用户进行确定。
ELISA：1：10,000 - 100,000
免疫组化：2-20 μg/mL。
最佳工作稀释度必须由最终用户进行确定。
Biochem/physiol Actions
小鼠前体食欲素。 最近已经报告了几种与进食行为有关的肽。 食欲素（食欲素-A和食欲素-B）是在下丘脑中选择性表达的下丘脑神经肽家族（Sakurai et al.1998）。 食欲素-A和食欲素-B通过蛋白水解裂解衍生自相同的前体（前体-食欲素）。 前体食欲素是一种130 aa的肽，具有假定的33 aa分泌序列，疏水核心，其后是带有小极性侧链的残基。 在脑中检测到该表达，在睾丸中检测到很小程度的表达（Sakurai et al.1998）。 这些神经肽结合并激活两个密切相关的食欲素受体-G蛋白偶联受体（GPCR）OX1R和OX2R。
Physical form
含0.1%BSA的PBS液体。
Preparation Note
可以在2-8°C下以未稀释的等分试样冷藏，以供短期使用。 若是保持冷冻在 -20°C 下，未稀释等分试样可保存长达 12 个月。
Other Notes
浓度：请参考批次特异性浓缩物的分析证书。
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Shuqin Zhan et al.
Journal of cellular and molecular medicine, 23(10), 6822-6834 (2019-08-07)
Hypocretin 1 and hypocretin 2 (orexin A and B) regulate sleep, wakefulness and emotion. Tumour necrosis factor alpha (TNF-α) is an important neuroinflammation mediator. Here, we examined the effects of TNF-α treatment on hypocretin expression in vivo and behaviour in
Finizia Russo et al.
Anatomical record (Hoboken, N.J. : 2007), 291(2), 169-174 (2008-01-24)
Orexin A (oxA) and orexin B are recently discovered peptides derived from the proteolytic cleavage of the common precursor prepro-orexin. They bind two G protein-coupled receptors, defined orexin 1 (ox1R) and orexin 2 receptor. Both peptides are highly expressed in
Luigi Michele Pavone et al.
Anatomical record (Hoboken, N.J. : 2007), 292(2), 202-206 (2008-12-18)
The hypothalamic peptide orexin A (oxA) binds specifically the G-protein-coupled orexin receptor 1 (ox1R). It is involved in many physiological functions including the regulation of food intake, sleep-wake cycle, arterial blood pressure, heart rate, and sexual behavior. The localization of
Giovanna Liguori et al.
BMC veterinary research, 14(1), 55-55 (2018-02-28)
Cryptorchidism is one of the most common birth disorders of the male reproductive system identified in dogs and other mammals. This condition is characterised by the absence of one (unilateral) or both (bilateral) gonads from the scrotum. The peptides orexin
Katie Sokolowski et al.
Neural development, 11(1), 12-12 (2016-05-23)
Neurons in the hypothalamus function to regulate the state of the animal during both learned and innate behaviors, and alterations in hypothalamic development may contribute to pathological conditions such as anxiety, depression or obesity. Despite many studies of hypothalamic development
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