Anti-ADAM 9 Antibody, disintegrin domain

A disintegrin and metalloproteinase domain-containing protein 9 (ADAM 9) belongs to a family of transmembrane, membrane-anchored, disintegrin-containing proteins that are involved in several biological functions such as protein ectodomain shedding, cell fusion, and cell adhesion. ADAMs contain several characteristic domains, two of which, the protease and disintegrin domains, are noted for their homology to snake venom metalloprotease. The exact function of ADAM 9 is yet unknown, however it is widely distributed, is found within keratinocytes, and is ideally placed on the cell membrane, which some studies have suggested supports a role in cell migration and motility. Alternative splicing results in two isoforms; isoform 1 is found within the cell membrane and is considered a single-pass type 1 membrane protein, while isoform 2 is secreted. Mutations in ADAM 9 expression are causal to cone-rod dystrophy type 9 or CORD9 which is characterized by visible retinal pigment deposits and loss of cone photoreceptors leading and rod degeneration, ultimately resulting in severe loss of vision.

Mouse and rat (90% sequence homology).

Epitope: disintegrin domain

KLH-conjugated linear peptide corresponding to the disintegrin domain of human ADAM 9.

Detect ADAM 9 using this Anti-ADAM 9 Antibody, disintegrin domain validated for use in WB.

Research Category
Cell Structure

Research Sub Category
MMPs & TIMPs

Evaluated by Western Blot in human chondrocyte cell lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected ADAM 9 in 10 µg of human chondrocyte cell lysate.

~ 90 kDa observed. 2 isoforms are produced by alternative splicing: Isoform 1 at 91 kDa and Isoform 2 at 72 kDa

Replaces: AB19025

Protein A purified

Format: Purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine, pH 7.4, 150 mM NaCl, with 0.05% sodium azide.

Stable for 1 year at 2-8°C from date of receipt.

Control
Human chondrocyte cell lysate

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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