AB2301

抗钙结合蛋白抗体

Name: 抗钙结合蛋白抗体
Brand: MM

from rabbit, purified by affinity chromatography

别名:

Calnexin, IP90, Major histocompatibility complex class I antigen-binding protein p88, p90

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关于此项目

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

主要文件

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产品名称

抗钙结合蛋白抗体, from rabbit, purified by affinity chromatography

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

mouse, rat, human, horse, pig

species reactivity (predicted by homology)

equine (based on 100% sequence homology), rhesus macaque (based on 100% sequence homology), chimpanzee (based on 100% sequence homology), bovine (based on 100% sequence homology), porcine (based on 100% sequence homology)

packaging

antibody small pack of 25 μL

technique(s)

immunocytochemistry: suitable
immunohistochemistry: suitable (paraffin)
western blot: suitable

NCBI accession no.

NP_001737

UniProt accession no.

P27824

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... CANX(821)

Application

抗钙联蛋白抗体是针对钙联蛋白的抗体，用于WB，IC，IH（P）。

研究子类别
发育神经科学

研究类别
神经科学

免疫细胞化学分析：一个代表性批次以 1：500 的稀释度在 NIH/3T3 细胞中检测到钙联蛋白。

免疫组化分析：一个代表性批次以 1：1,000-2,000 的稀释度在人脑和前列腺组织中检测到了钙联蛋白。

Biochem/physiol Actions

该抗体识别钙联蛋白的 C 端。

Analysis Note

对照
人脑组织裂解液

通过蛋白质印迹在人脑组织裂解物中进行了评估。

蛋白质印迹分析：该抗体以 1：10,000 的稀释度在 10 µg 人脑组织裂解液中检测到钙联蛋白。

Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

General description

观测值〜70 kDa

钙联蛋白是在 ER 跨膜中发现的 Ca ++ 结合蛋白，其与在新合成的蛋白上发现的特定的 n-连接的寡糖结合。钙联蛋白与 ER 膜磷酸糖蛋白、信号序列受体 SSRμ 结合，并已被确定为与主要组织相容性复合物（MHC）I 类重链结合，以及在组装这些多聚体复合物之前与 T 细胞受体和膜免疫球蛋白结合的 ER 蛋白。因此，钙联蛋白可以代表一种 ER 膜中的分子伴侣，其对新转移至 ER 的不完全折叠的寡聚膜蛋白具有选择性。

Immunogen

KLH 偶联的线性肽，对应于人钙联蛋白的 C 末端。

表位：C端

Other Notes

浓度：请参考批次特异性浓缩物的分析证书。

Physical form

亲和纯化

在含 0.1 M Tris-甘氨酸（pH 7.4），150 mM NaCl 和 0.05％叠氮化钠的缓冲液中的纯化的兔多克隆抗体。

Preparation Note

自收到之日起，在 2-8°C 条下可稳定保存 1 年。

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存储类别

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

常规特殊物品

此项目有

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A calcium-sensing receptor mutation causing hypocalcemia disrupts a transmembrane salt bridge to activate β-arrestin-biased signaling.

Caroline M Gorvin et al.

Science signaling, 11(518) (2018-02-22)

The calcium-sensing receptor (CaSR) is a G protein-coupled receptor (GPCR) that signals through Gq/11 and Gi/o to stimulate cytosolic calcium (Ca2+i) and mitogen-activated protein kinase (MAPK) signaling to control extracellular calcium homeostasis. Studies of loss- and gain-of-function CASR mutations, which

Calcium-sensing receptor residues with loss- and gain-of-function mutations are located in regions of conformational change and cause signalling bias.

Caroline M Gorvin et al.

Human molecular genetics, 27(21), 3720-3733 (2018-07-28)

The calcium-sensing receptor (CaSR) is a homodimeric G-protein-coupled receptor that signals via intracellular calcium (Ca2+i) mobilisation and phosphorylation of extracellular signal-regulated kinase 1/2 (ERK) to regulate extracellular calcium (Ca2+e) homeostasis. The central importance of the CaSR in Ca2+e homeostasis has

Circulating small extracellular vesicles increase after an acute bout of moderate-intensity exercise in pregnant compared to non-pregnant women.

Shuhiba Mohammad et al.

Scientific reports, 11(1), 12615-12615 (2021-06-18)

The physiological and molecular mechanisms linking prenatal physical activity and improvements in maternal-fetal health are unknown. It is hypothesized that small extracellular vesicles (EVs, ~ 10-120 nm) are involved in tissue cross-talk during exercise. We aimed to characterize the circulating small EV profile

The N-terminal region of Jaw1 has a role to inhibit the formation of organized smooth endoplasmic reticulum as an intrinsically disordered region.

Takuma Kozono et al.

Scientific reports, 11(1), 753-753 (2021-01-14)

Jaw1/LRMP is a type II integral membrane protein that is localized at the endoplasmic reticulum (ER) and outer nuclear membrane. We previously reported that a function of Jaw1 is to maintain the nuclear shape as a KASH protein via its

Nucleus accumbens GLT-1a overexpression reduces glutamate efflux during reinstatement of cocaine-seeking but is not sufficient to attenuate reinstatement.

Carly N Logan et al.

Neuropharmacology, 135, 297-307 (2018-03-24)

Cocaine use disorder is a chronically relapsing disease without FDA-approved treatments. Using a rodent model of cocaine relapse, we and others have previously demonstrated that the beta-lactam antibiotic ceftriaxone attenuates cue- and cocaine-primed reinstatement of cocaine-seeking. Ceftriaxone restores cocaine-induced deficits

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抗钙结合蛋白抗体

from rabbit, purified by affinity chromatography

选择尺寸

关于此项目

主要文件

属性

产品名称

biological source

conjugate

antibody form

antibody product type

clone

purified by

species reactivity

species reactivity (predicted by homology)

packaging

technique(s)

NCBI accession no.

UniProt accession no.

shipped in

target post-translational modification

Quality Level

Gene Information

相关类别

说明

Application

Biochem/physiol Actions

Analysis Note

Disclaimer

General description

Immunogen

Other Notes

Physical form

Preparation Note

安全信息

存储类别

wgk

flash_point_f

flash_point_c

法规信息

文件

分析证书(COA)

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