AB2266
Anti-VPAC2 Antibody
from rabbit, purified by affinity chromatography
别名:
vasoactive intestinal peptide receptor 2, Helodermin-preferring VIP receptor, Pituitary adenylate cyclase-activating polypeptide type III receptor, vasoactive intestinal polypeptide receptor 2, PACAP type III receptor
登录查看公司和协议定价
所有图片(2)
About This Item
UNSPSC代码:
12352203
eCl@ss:
32160702
NACRES:
NA.41
生物来源
rabbit
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
纯化方式
affinity chromatography
种属反应性
human
种属反应性（根据同源性预测）
pig (based on 100% sequence homology), bovine (based on 100% sequence homology), rhesus macaque (based on 100% sequence homology), rat (based on 100% sequence homology)
技术
immunohistochemistry: suitable (paraffin)
western blot: suitable
NCBI登记号
UniProt登记号
运输
wet ice
靶向翻译后修饰
unmodified
基因信息
human ... VIPR2(7434)
一般描述
Vasoactive intestinal polypeptide receptor 2 (VPAC2), also known as PACAP type III receptor or PACAP-R3 for short, is a class B G-protein-coupled receptor. Three distinct PACAP receptors have been identified. Of the three, only PACAP-3 has been found expressed in Sartoli cells of the testis and is coupled to G and adenylyl cyclase, thus having a potential influence on the production of cAMP. In the immune system, PACAP-R3 is expressed on stimulated CD4 T cells, and binding of T cell-derived VIP to-PACAP-R3 induces a shift toward the Th2 pathway. In addition, PACAP-R3 is an essential regulator of the circadian pacemaker of the hypothalamic suprachiasmatic nuclei (SCN).
特异性
Other homologies: mouse (84% sequence homology).
This antibody recognizes VCAP2 (PACAP-R3) at the extracellular domain.
免疫原
KLH-conjugated linear peptide corresponding to the extracellular domain of human VPAC2 (PACAP-R3).
应用
Anti-VPAC2 Antibody is an antibody against VPAC2 for use in WB, IH(P).
Immunohistochemistry Analysis: 1:400 dilution from a previous lot detected VPAC2 in normal human cerebral cortex and T cells inside the mantle zone of normal human tonsil tissues.
质量
Evaluated by Western Blot in Jurkat cell lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected VPAC2 on 10 µg of Jurkat cell lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected VPAC2 on 10 µg of Jurkat cell lysate.
目标描述
~52 kDa observed. An uncharacterized band appears at ~39 kDa in some lysates.
其他说明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Not finding the right product?
Try our 产品选型工具.
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Liwen Chen et al.
Investigative ophthalmology & visual science, 59(7), 2848-2860 (2018-07-20)
To investigate the roles of vasoactive intestinal peptides (VIPs) in regulating the morphology and F-actin distribution of Schlemm's canal (SC) of rat eyes. Chronic intraocular pressure (IOP) hypertension models with episcleral venous cauterization (EVC) were treated with topical VIP or
Xiaoqin Yan et al.
Investigative ophthalmology & visual science, 61(6), 45-45 (2020-06-24)
A previous study reported that vasoactive intestinal peptide (VIP) can regulate the cytoskeleton of Schlemm's canal (SC) endothelium and expand the SC lumen in a rat glaucoma model. In this study, we aimed to investigate the molecular mechanism of VIP
Jayden Lee et al.
International journal of molecular sciences, 24(13) (2023-07-14)
Neuropsychiatric systemic lupus erythematosus (NPSLE) is one of the most common and severe manifestations of lupus; however, its pathogenesis is still poorly understood. While there is sparse evidence suggesting that the ongoing autoimmunity may trigger pathogenic changes to the central
Ana Florencia Vega-Benedetti et al.
International journal of molecular sciences, 21(12) (2020-07-01)
Colorectal cancer (CRC) is a major cause of cancer mortality. Early diagnosis is relevant for its prevention and treatment. Since DNA methylation alterations are early events in tumourigenesis and can be detected in cell-free DNA, they represent promising biomarkers for
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门