产品名称
抗水通道蛋白4抗体, Chemicon®, from rabbit
biological source
rabbit
Quality Level
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
human, mouse, rat
manufacturer/tradename
Chemicon®
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... AQP4(361)
General description
~34 kDa
水特异性通道水通道蛋白4位于包括胃肠道、肾脏和大脑在内的各种组织中。它是一种渗透压感受器，可调节体内水的平衡并介导中央神经紧张的系统内的水流。 AQ4在星形胶质细胞末端的定位使其成为星形胶质细胞远端过程的极佳标记。
Immunogen
表位：C端
Application
抗水通道蛋白4抗体是针对水通道蛋白4的抗体，可用于WB。
研究类别
神经科学
神经科学
蛋白质印迹：0.5-1 μg/mL，使用化学发光技术。
最佳工作稀释度必须由最终用户进行确定。
最佳工作稀释度必须由最终用户进行确定。
Biochem/physiol Actions
尚未检测该抗体与其他种属的交叉反应性。免疫原与小鼠的相似性为94%，与牛的相似性为88%，与兔的相似性为86%，与人AQP4（hAQP4）的相似性为82%。
Physical form
在含0.05% NaN3的PBS中纯化
Preparation Note
自收到之日起，在 2-8° 以未稀释的等分试样可保存 1 年。
Analysis Note
对照
对成年大鼠脑裂解液进行检测
对成年大鼠脑裂解液进行检测
Other Notes
替代品：AB3068
浓度：请参考批次特异性浓缩物的检验报告。
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Romain Marignier et al.
Brain : a journal of neurology, 133(9), 2578-2591 (2010-08-07)
Devic's neuromyelitis optica is an inflammatory demyelinating disorder normally restricted to the optic nerves and spinal cord. Since the identification of a specific autoantibody directed against aquaporin 4, neuromyelitis optica-immunoglobulin G/aquaporin 4 antibody, neuromyelitis optica has been considered an entity
Erika Bindocci et al.
Science (New York, N.Y.), 356(6339) (2017-05-20)
Astrocyte communication is typically studied by two-dimensional calcium ion (Ca2+) imaging, but this method has not yielded conclusive data on the role of astrocytes in synaptic and vascular function. We developed a three-dimensional two-photon imaging approach and studied Ca2+ dynamics
Stefanie Gurnik et al.
Acta neuropathologica, 131(5), 753-773 (2016-03-05)
The homeostasis of the central nervous system is maintained by the blood-brain barrier (BBB). Angiopoietins (Ang-1/Ang-2) act as antagonizing molecules to regulate angiogenesis, vascular stability, vascular permeability and lymphatic integrity. However, the precise role of angiopoietin/Tie2 signaling at the BBB
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| AB2218 | 04053252275920 |