推荐产品
生物来源
rabbit
质量水平
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
纯化方式
affinity chromatography
种属反应性
human, mouse, rat
制造商/商品名称
Chemicon®
技术
western blot: suitable
NCBI登记号
UniProt登记号
运输
wet ice
靶向翻译后修饰
unmodified
基因信息
human ... AQP4(361)
一般描述
水特异性通道水通道蛋白4位于包括胃肠道、肾脏和大脑在内的各种组织中。它是一种渗透压感受器,可调节体内水的平衡并介导中央神经紧张的系统内的水流。 AQ4在星形胶质细胞末端的定位使其成为星形胶质细胞远端过程的极佳标记。
特异性
可识别水通道蛋白4。
尚未检测该抗体与其他种属的交叉反应性。免疫原与小鼠的相似性为94%,与牛的相似性为88%,与兔的相似性为86%,与人AQP4(hAQP4)的相似性为82%。
免疫原
合成线性肽
表位:C端
应用
抗水通道蛋白4抗体是针对水通道蛋白4的抗体,可用于WB。
研究子类别
离子通道 & 转运体
离子通道 & 转运体
研究类别
神经科学
神经科学
蛋白质印迹:0.5-1 μg/mL,使用化学发光技术。
最佳工作稀释度必须由最终用户进行确定。
最佳工作稀释度必须由最终用户进行确定。
目标描述
~34 kDa
联系
替代品:AB3068
外形
免疫亲和纯化
在含0.05% NaN3的PBS中纯化
储存及稳定性
自收到之日起,在 2-8° 以未稀释的等分试样可保存 1 年。
分析说明
对照
对成年大鼠脑裂解液进行检测
对成年大鼠脑裂解液进行检测
其他说明
浓度:请参考批次特异性浓缩物的检验报告。
法律信息
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Acta neuropathologica, 131(5), 753-773 (2016-03-05)
The homeostasis of the central nervous system is maintained by the blood-brain barrier (BBB). Angiopoietins (Ang-1/Ang-2) act as antagonizing molecules to regulate angiogenesis, vascular stability, vascular permeability and lymphatic integrity. However, the precise role of angiopoietin/Tie2 signaling at the BBB
PloS one, 15(9), e0238301-e0238301 (2020-09-04)
Neuromyelitis optica spectrum disorders (NMOSD) is a primary astrocytopathy driven by antibodies directed against the aquaporin-4 water channel located at the end-feet of the astrocyte. Although blood-brain barrier (BBB) breakdown is considered one of the key steps for the development
Frontiers in cellular neuroscience, 9, 456-456 (2015-12-10)
The serine protease tissue-type plasminogen activator (tPA) is used as a thrombolytic agent in the management of ischemic stroke, but concerns for hemorrhagic conversion greatly limits the number of patients that receive this treatment. It has been suggested that the
Brain : a journal of neurology, 133(9), 2578-2591 (2010-08-07)
Devic's neuromyelitis optica is an inflammatory demyelinating disorder normally restricted to the optic nerves and spinal cord. Since the identification of a specific autoantibody directed against aquaporin 4, neuromyelitis optica-immunoglobulin G/aquaporin 4 antibody, neuromyelitis optica has been considered an entity
Science (New York, N.Y.), 356(6339) (2017-05-20)
Astrocyte communication is typically studied by two-dimensional calcium ion (Ca2+) imaging, but this method has not yielded conclusive data on the role of astrocytes in synaptic and vascular function. We developed a three-dimensional two-photon imaging approach and studied Ca2+ dynamics
我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门