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AB2218

Sigma-Aldrich

抗水通道蛋白4抗体

Chemicon®, from rabbit

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别名:
AQP4, WCH4, MIWC
UNSPSC代码:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物来源

rabbit

质量水平

抗体形式

affinity isolated antibody

抗体产品类型

primary antibodies

克隆

polyclonal

纯化方式

affinity chromatography

种属反应性

human, mouse, rat

制造商/商品名称

Chemicon®

技术

western blot: suitable

UniProt登记号

运输

wet ice

靶向翻译后修饰

unmodified

基因信息

human ... AQP4(361)

一般描述

水特异性通道水通道蛋白4位于包括胃肠道、肾脏和大脑在内的各种组织中。它是一种渗透压感受器,可调节体内水的平衡并介导中央神经紧张的系统内的水流。 AQ4在星形胶质细胞末端的定位使其成为星形胶质细胞远端过程的极佳标记。

特异性

可识别水通道蛋白4。
尚未检测该抗体与其他种属的交叉反应性。免疫原与小鼠的相似性为94%,与牛的相似性为88%,与兔的相似性为86%,与人AQP4(hAQP4)的相似性为82%。

免疫原

合成线性肽
表位:C端

应用

抗水通道蛋白4抗体是针对水通道蛋白4的抗体,可用于WB。
研究子类别
离子通道 & 转运体
研究类别
神经科学
蛋白质印迹:0.5-1 μg/mL,使用化学发光技术。

最佳工作稀释度必须由最终用户进行确定。

目标描述

~34 kDa

联系

替代品:AB3068

外形

免疫亲和纯化
在含0.05% NaN3的PBS中纯化

储存及稳定性

自收到之日起,在 2-8° 以未稀释的等分试样可保存 1 年。

分析说明

对照
对成年大鼠脑裂解液进行检测

其他说明

浓度:请参考批次特异性浓缩物的检验报告。

法律信息

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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Stefanie Gurnik et al.
Acta neuropathologica, 131(5), 753-773 (2016-03-05)
The homeostasis of the central nervous system is maintained by the blood-brain barrier (BBB). Angiopoietins (Ang-1/Ang-2) act as antagonizing molecules to regulate angiogenesis, vascular stability, vascular permeability and lymphatic integrity. However, the precise role of angiopoietin/Tie2 signaling at the BBB
Alvaro Cobo-Calvo et al.
PloS one, 15(9), e0238301-e0238301 (2020-09-04)
Neuromyelitis optica spectrum disorders (NMOSD) is a primary astrocytopathy driven by antibodies directed against the aquaporin-4 water channel located at the end-feet of the astrocyte. Although blood-brain barrier (BBB) breakdown is considered one of the key steps for the development
Christina Stefanitsch et al.
Frontiers in cellular neuroscience, 9, 456-456 (2015-12-10)
The serine protease tissue-type plasminogen activator (tPA) is used as a thrombolytic agent in the management of ischemic stroke, but concerns for hemorrhagic conversion greatly limits the number of patients that receive this treatment. It has been suggested that the
Romain Marignier et al.
Brain : a journal of neurology, 133(9), 2578-2591 (2010-08-07)
Devic's neuromyelitis optica is an inflammatory demyelinating disorder normally restricted to the optic nerves and spinal cord. Since the identification of a specific autoantibody directed against aquaporin 4, neuromyelitis optica-immunoglobulin G/aquaporin 4 antibody, neuromyelitis optica has been considered an entity
Erika Bindocci et al.
Science (New York, N.Y.), 356(6339) (2017-05-20)
Astrocyte communication is typically studied by two-dimensional calcium ion (Ca2+) imaging, but this method has not yielded conclusive data on the role of astrocytes in synaptic and vascular function. We developed a three-dimensional two-photon imaging approach and studied Ca2+ dynamics

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