生物来源
rabbit
质量水平
抗体形式
serum
抗体产品类型
primary antibodies
克隆
polyclonal
种属反应性
human, mouse, rat
技术
western blot: suitable
GenBank登记号
UniProt登记号
运输
wet ice
靶向翻译后修饰
unmodified
基因信息
mouse ... Per1(18626)
一般描述
该基因是Period基因家族的成员，并在视交叉上核（哺乳动物脑中的主要昼夜节律起搏器）中以昼夜节律模式表达。该家族中的基因编码运动活动，代谢和行为的昼夜节律的组成部分。视交叉上核中的昼夜节律表达在恒定的黑暗中继续进行，并且明/暗周期的变化引起视交叉上核中基因表达的比例变化。该基因的特定功能尚不清楚。在该基因中观察到了选择性剪接。但是，这些变体尚未得到充分描述。
特异性
基于序列同源性，可能与果蝇、尼罗罗非鱼和黄金仓鼠反应。 与其他物种的反应性尚未得到测试。
目录#AB2201将识别mPer1的N端。
应用
使用经验证可用于WB的抗mPER1（残基6-21）抗体检测mPER1（残基6-21）。
免疫组化：
在全脑上进行了测试（SCN；CT/ZT12的峰值染色）。 需要根据最终使用情况确定最佳工作稀释度。
在全脑上进行了测试（SCN；CT/ZT12的峰值染色）。 需要根据最终使用情况确定最佳工作稀释度。
质量
通过蛋白质印迹法对人脑裂解液进行常规测试
目标描述
136 kDa
法律信息
GenBank is a registered trademark of United States Department of Health and Human Services
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WGK
WGK 1
Wenhao Ge et al.
Journal of lipid research, 64(6), 100390-100390 (2023-05-21)
Several epidemiological studies suggest a correlation between eating time and obesity. Night eating syndrome characterized by a time-delayed eating pattern is positively associated with obesity in humans as well as in experimental animals. Here, we show that oil intake at
Circadian key component CLOCK/BMAL1 interferes with segmentation clock in mouse embryonic organoids.
Yasuhiro Umemura et al.
Proceedings of the National Academy of Sciences of the United States of America, 119(1) (2021-12-22)
In mammals, circadian clocks are strictly suppressed during early embryonic stages, as well as in pluripotent stem cells, by the lack of CLOCK/BMAL1-mediated circadian feedback loops. During ontogenesis, the innate circadian clocks emerge gradually at a late developmental stage, and
Nobuko Katoku-Kikyo et al.
PLoS biology, 21(12), e3002419-e3002419 (2023-12-04)
Circadian regulation of gene expression is prevalent and plays critical roles in cell differentiation. However, its roles in the reprogramming of differentiated cells remain largely unknown. Here, we found that one of the master circadian regulators PER1 promoted virus-mediated reprogramming
Tomoko Ikeno et al.
Journal of biological rhythms, 31(4), 352-364 (2016-04-15)
In mammals, the circadian system is composed of a principal circadian oscillator located in the suprachiasmatic nucleus (SCN) and a number of subordinate oscillators in extra-SCN brain regions and peripheral tissues/organs. However, how the time-keeping functions of this multiple oscillator
Floriana Mogavero et al.
The European journal of neuroscience, 55(6), 1492-1503 (2022-03-02)
Although aggression has been linked to disturbances of circadian rhythm, insight into the neural substrate of this association is currently lacking. The suprachiasmatic nucleus (SCN) of the hypothalamus, the master circadian clock, is regulated by clock genes and known to
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