生物来源
rabbit
质量水平
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
纯化方式
affinity chromatography
种属反应性
mouse, human
制造商/商品名称
Chemicon®
技术
immunohistochemistry: suitable (paraffin)
western blot: suitable
NCBI登记号
UniProt登记号
运输
dry ice
靶向翻译后修饰
unmodified
基因信息
human ... TNC(3371)
一般描述
Tenascin is known to play an active role in development of central nervous system and mesenchymal-derived organs, exist in the vasculature of tumors in adults, and function in cell adhesion.
特异性
Reactivity with other species has not been confirmed, but likely to react with all mammalian species.
Reacts strongly with tenascin from human and mouse in both Western blotting and immunohistochemistry. While it has not been tested, it should also react strongly in these applications with tenascin from all mammalian species.
免疫原
Purified human tenascin from glioma culture supernatant.
应用
Research Category
Cell Structure
Cell Structure
Research Sub Category
ECM Proteins
ECM Proteins
This Anti-Tenascin Antibody is validated for use in WB, IH(P) for the detection of Tenascin.
Western blot: 0.5 - 1.0 μg/mL; recognizes 250-350 kDa polypeptides in reduced samples.
Immunohistochemistry: 10 to 20 μg/mL in paraffin embedded tissues
Optimal working dilutions must be determined by end user.
Immunohistochemistry: 10 to 20 μg/mL in paraffin embedded tissues
Optimal working dilutions must be determined by end user.
外形
Affinity purified using immobilized human tenascin; presented as a liquid in PBS containing no preservatives.
储存及稳定性
Maintain at -20°C for up to 12 months from date of receipt. Aliquot to avoid repeated freeze/thaw cycles.
法律信息
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Subhayan Sur et al.
International journal of molecular sciences, 22(6) (2021-04-04)
SARS-CoV-2 infection can cause cytokine storm and may overshoot immunity in humans; however, it remains to be determined whether virus-induced soluble mediators from infected cells are carried by exosomes as vehicles to distant organs and cause tissue damage in COVID-19
Minsuk Choi et al.
Cancer research, 78(24), 6890-6902 (2018-10-26)
: Although cancer stem cells (CSC) are thought to be responsible for tumor recurrence and resistance to chemotherapy, CSC-related research and drug development have been hampered by the limited supply of diverse, patient-derived CSC. Here, we present a functional polymer
Fernando García-Marqués et al.
Molecular & cellular proteomics : MCP, 15(5), 1740-1760 (2016-02-20)
The coordinated behavior of proteins is central to systems biology. However, the underlying mechanisms are poorly known and methods to analyze coordination by conventional quantitative proteomics are still lacking. We present the Systems Biology Triangle (SBT), a new algorithm that
Loss of caveolin-1 from bronchial epithelial cells and monocytes in human subjects with asthma.
Bains, SN; Tourkina, E; Atkinson, C; Joseph, K; Tholanikunnel, B; Chu, HW; Riemer et al.
Allergy null
Mariska T Meijer et al.
Frontiers in immunology, 12, 600979-600979 (2021-03-30)
Tenascin C (TNC) is an extracellular matrix glycoprotein that recently emerged as an immunomodulator. TNC-deficient (TNC-/-) mice were reported to have a reduced inflammatory response upon systemic administration of lipopolysaccharide, the toxic component of gram-negative bacteria. Here, we investigated the
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