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AB1781SP

Sigma-Aldrich

Anti-Neurotrophin 4/5 Antibody

Chemicon®, from rabbit

别名:

NT4/5

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About This Item

UNSPSC代码:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物来源

rabbit

质量水平

抗体形式

purified immunoglobulin

抗体产品类型

primary antibodies

克隆

polyclonal

种属反应性

rat, monkey, human, mouse

制造商/商品名称

Chemicon®

技术

ELISA: suitable
immunohistochemistry: suitable
western blot: suitable

NCBI登记号

UniProt登记号

运输

dry ice

靶向翻译后修饰

unmodified

基因信息

human ... NTF4(4909)

特异性

Neurotrophin 4 (NT4). By dot blot, less than 1% cross-reactivity against NGF, BDNF or NT3.

免疫原

Recombinant human Neurotrophin 4 (NT4).

应用

Anti-Neurotrophin 4/5 Antibody is an antibody against Neurotrophin 4/5 for use in ELISA, WB, IH.
Immunohistochemistry: 1-2 μg/mL (see suggested protocol).

Immunoblotting: 1-2 μg/mL

ELISA: 1-2 μg/mL

Inhibition of biological activity in vitro: 1-2 μg/mL.
BIOLOGICAL ACTIVITY: Neutralizes NT4, but not other neurotrophins.

In vivo animal studies: use neat

Optimal working dilutions must be determined by end user.
Research Category
Neuroscience
Research Sub Category
Neurochemistry & Neurotrophins

联系

Replaces: AB1455P

外形

Format: Purified
Purified immunoglobulin. Lyophilized from PBS, no preservatives. Reconstitute with 500 μL of sterile distilled water (1 mg/mL).

储存及稳定性

Maintain lyophilized material at -20 to -70°C for up to 12 months after date of receipt. After reconstitution maintain at -20 to -70°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.

法律信息

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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R Cabo et al.
Anatomical record (Hoboken, N.J. : 2007), 298(3), 624-629 (2014-09-19)
Some mechanoreceptors in mammals depend totally or in part on the neurotrophins brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT-4), and their receptor TrkB, for development and maintenance. These actions are presumably exerced regulating the survival of discrete sensory neurons in
Takahiro Ishimoto et al.
NPJ science of food, 8(1), 11-11 (2024-02-07)
Oral administration of the food-derived antioxidant amino acid ergothioneine (ERGO) results in its efficient distribution in the brain and enhances cognitive function. However, effect of ERGO deficiency on cognitive impairment and the underlying mechanisms remain unknown. We revealed that cognitive
Erica Hurtado et al.
Frontiers in molecular neuroscience, 10, 147-147 (2017-06-03)
The neurotrophin brain-derived neurotrophic factor (BDNF) acts via tropomyosin-related kinase B receptor (TrkB) to regulate synapse maintenance and function in the neuromuscular system. The potentiation of acetylcholine (ACh) release by BDNF requires TrkB phosphorylation and Protein Kinase C (PKC) activation.

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