生物来源
rabbit
质量水平
抗体形式
serum
抗体产品类型
primary antibodies
克隆
polyclonal
种属反应性
mouse, human, rat, rabbit
制造商/商品名称
Chemicon®
技术
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
UniProt登记号
运输
dry ice
靶向翻译后修饰
unmodified
基因信息
human ... BID(637)
一般描述
Bid, a BH3 domain-containing proapoptotic Bcl-2 family member, is known to interact with Bcl-2 and Bax. It has been reported that Bid induces cytochrome c release from mitochondria following cleavage by caspase-8 in response to apoptotic stimuli transmitted through cell surface death receptors. The cytochrome c releasing activity of Bid was antagonized by Bcl-2. Mutation in the SH3 domain can diminish the cytochrome c releasing activity. In animal model studies, Bid-deficient mice are found resistant to the lethal effects of death factor signals relayed through Fas.
特异性
AB1735 recognizes Bid from human, mouse, rat and rabbit.
免疫原
Recombinant full length GST-tagged mouse Bid protein
应用
Detect Bid using this Anti-Bid Antibody validated for use in WB, IP, IH.
Research Category
Apoptosis & Cancer
Apoptosis & Cancer
Research Sub Category
BCL2 & Inhibition
BCL2 & Inhibition
Western blot: Recommended antibody dilution 1:3,000 to 1:6,000. Recognizes a band migrating at approximately 22 kDa corresponding to Bid.
Immunoprecipitation: Recommended antibody dilution 1:200
Immunohistochemistry: Recommended antibody dilution 1:1500
Optimal working dilutions must be determined by end user.
Immunoprecipitation: Recommended antibody dilution 1:200
Immunohistochemistry: Recommended antibody dilution 1:1500
Optimal working dilutions must be determined by end user.
联系
Replaces: 04-438
外形
Whole serum without preservatives
储存及稳定性
Store at -20°C for up to 12 months.
法律信息
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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BACKGROUND Hypertension-related microRNA(miR)-1283 and its target gene, activating transcription factor-4 (ATF4), can regulate vascular endothelial dysfunction. This study aimed to explore whether miR-1283 prevents hypertension through targeting ATF4. MATERIAL AND METHODS Transcriptome sequencing was performed after overexpression or inhibition of
Atsushi Suzuki et al.
Oncogene, 22(40), 6177-6182 (2003-09-19)
AMPK is a serine/threonine protein kinase family and we recently identified a novel member, ARK5. The activation of ARK5 is triggered by Akt, and ARK5 induces tumor cell survival during nutrient starvation. In the current study, we investigated the mechanisms
Min Xu et al.
Glia, 62(6), 855-880 (2014-03-13)
The roles of cathepsins in the ischemic astrocytic injury remain unclear. Here, we test the hypothesis that activation of cathepsin B and L contributes to the ischemic astrocyte injury via the tBid-mitochondrial apoptotic signaling pathways. In the rat models of
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