AB15392
Anti-Zic2 Antibody
from rabbit, purified by affinity chromatography
别名:
Zic family member 2 (odd-paired Drosophila homolog), Zic family member 2 (odd-paired homolog, Drosophila), Zinc finger protein of the cerebellum 2
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所有图片(2)
About This Item
UNSPSC代码:
12352203
eCl@ss:
32160702
NACRES:
NA.41
推荐产品
生物来源
rabbit
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
纯化方式
affinity chromatography
种属反应性
mouse
种属反应性（根据同源性预测）
human (based on 100% sequence homology), bovine (based on 100% sequence homology), monkey (based on 100% sequence homology), rat (based on 100% sequence homology)
技术
immunohistochemistry: suitable
western blot: suitable
NCBI登记号
UniProt登记号
运输
wet ice
靶向翻译后修饰
unmodified
基因信息
mouse ... Zic2(22772)
一般描述
Zinc-finger transcription factor (Zic2) is a conserved signaling protein with critical roles in neural development including neurulation, anteroposterior patterning, neural crest formation, cerebellar development, and ipsilateral axonal targeting across the optic chiasm. It activates the transcription of target genes by DNA binding and recruitment of RNA helicase A (RHA). Zic2 has been shown to operate as a transcriptional repressor of cellular proliferation and neurogenesis. Zic2 is expressed in pluripotent cells in the blastocyst and adult brain expression overlaps with markers of neurogenesis. The Zic2kd/kd mice show holoprosencephaly and spina bifida, which derive from malformations in the anterior and posterior ends of the neural tube, respectively. Due to its apparent role in the regulation of granule cell expansion, Zic2 expression is a useful marker for mature granule neurons in the developing cerebellum.
特异性
This antibody recognizes Zic2.
免疫原
Epitope: This antibody recognizes Zic2 at the N-terminus region.
This antibody is generated from rabbits immunized with a GST-tagged recombinant protein corresponding to residues in the N-terminus of mouse Zic2.
应用
Anti-Zic2 Antibody is an antibody against Zic2 for use in WB, IH.
Immunohistochemistry Analysis: 1:200 dilution from a previous lot detected Zic2 on mouse cerebellum and hippocampus tissue.
质量
Evaluated by Western Blot in mouse cerebellum lysate.
Western Blot Analysis: : 0.1 µg/ml of this antibody detected Zic2 on 10 µg of mouse cerebellum lysate.
Western Blot Analysis: : 0.1 µg/ml of this antibody detected Zic2 on 10 µg of mouse cerebellum lysate.
目标描述
55 kDa
其他说明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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Proceedings of the National Academy of Sciences of the USA null
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