AB1252
抗细胞色素P450 酶CYP2E1抗体
serum, Chemicon®
别名:
cytochrome P450 2E1, cytochrome P450, family 2, subfamily E, polypeptide 1, cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1, flavoprotein-linked monooxygenase, microsomal monooxygenase, xenobiotic monooxygenase
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IHC, WB
Citations:
41
biological source
rabbit
conjugate
unconjugated
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
rat, human, mouse
manufacturer/tradename
Chemicon®
technique(s)
immunohistochemistry: suitable, western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... CYP2E1(1571)
mouse ... Cyp2E1(13106)
rat ... Cyp2E1(25086)
General description
57kda
细胞色素P450 （CYP）是一个巨大的、多样化的血红素蛋白超家族。它可以将脂肪酸花生四烯酸（AA）代谢为血管紧张度的调节因子。
大多数CYP可以代谢多种底物，并且可以催化多种反应。这种作用导致它们在诸多内源性和外源性分子的代谢中极为重要。在肝脏中，这些底物包括药物和毒性化合物，以及代谢产物，如胆红素（血红蛋白的分解产物）。细胞色素P450 酶存在于机体的许多其它组织中，包括胃肠道的粘膜，并在激素合成和分解（包括雌激素和睾丸素合成和代谢）、胆固醇合成和维生素D代谢中起重要作用。自2007年9月以来，我们已经知道了7700多种不同的CYP序列。
大多数CYP可以代谢多种底物，并且可以催化多种反应。这种作用导致它们在诸多内源性和外源性分子的代谢中极为重要。在肝脏中，这些底物包括药物和毒性化合物，以及代谢产物，如胆红素（血红蛋白的分解产物）。细胞色素P450 酶存在于机体的许多其它组织中，包括胃肠道的粘膜，并在激素合成和分解（包括雌激素和睾丸素合成和代谢）、胆固醇合成和维生素D代谢中起重要作用。自2007年9月以来，我们已经知道了7700多种不同的CYP序列。
Application
免疫组化：
一个先前批次被用于甲醛处理的冷冻切片。
最佳的工作稀释度必须由最终用户确定。
一个先前批次被用于甲醛处理的冷冻切片。
最佳的工作稀释度必须由最终用户确定。
抗细胞色素P450 酶CYP2E1抗体是针对细胞色素P450 酶CYP2E1的抗体，可用于IH & WB。
Biochem/physiol Actions
与肝脏微粒体部分（microsomal fraction）中的人和大鼠细胞色素P450 酶CYP2E1反应。与这些物种中的其它细胞色素P450 酶没有交叉反应。
Physical form
不含防腐剂的缓冲液中的兔多克隆抗血清。
Analysis Note
对照
肝脏组织。
肝脏组织。
通过蛋白质印迹对人脑裂解物进行了评估。
蛋白质印迹分析：
该抗体的1：1000稀释液在10 μg小人脑裂解物中检测到细胞色素P450 酶CYP2E1。
蛋白质印迹分析：
该抗体的1：1000稀释液在10 μg小人脑裂解物中检测到细胞色素P450 酶CYP2E1。
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Mohammed A Assiri et al.
Alcoholism, clinical and experimental research, 41(10), 1705-1714 (2017-08-15)
Chronic ethanol (EtOH) consumption is a major cause of liver disease worldwide. Oxidative stress is a known consequence of EtOH metabolism and is thought to contribute significantly to alcoholic liver disease (ALD). Therefore, elucidating pathways leading to sustained oxidative stress
Xiaoxia Jin et al.
Frontiers in pharmacology, 9, 1317-1317 (2018-12-14)
This study was designed to explore the role of cytochrome P4502E1 (CYP2E1) expression in the course of brain edema induced by subacute poisoning with 1,2-dichloroethane (1,2-DCE). Mice were randomly divided into five groups: the control group, the 1,2-DCE poisoned group
Rebecca L McCullough et al.
Molecular immunology, 75, 122-132 (2016-06-10)
Complement is implicated in the development of alcoholic liver disease. C3 and C5 contribute to ethanol-induced liver injury; however, the role of C5a receptor (C5aR) on myeloid and non-myeloid cells to progression of injury is not known. C57BL/6 (WT), global
Kyle J Thompson et al.
Alcohol and alcoholism (Oxford, Oxfordshire), 52(6), 629-637 (2017-10-17)
This study sought to compare mice bred to preferentially consume high amounts of alcohol (crossed-high alcohol preferring, cHAP) to c57BL/6 (C57) mice using a chronic-binge ethanol ingestion model to induce alcoholic liver disease (ALD). Male C57 and cHAP mice were
Pengcheng Wang et al.
Biochemical pharmacology, 145, 218-225 (2017-09-11)
Acetylation is the major metabolic pathway of isoniazid (INH) mediated by N-acetyltransferases (NATs). Previous reports suggest that slow acetylators have higher risks of INH hepatotoxicity than rapid acetylators, but the detailed mechanisms remain elusive. The current study used Nat1/2(-/-) mice
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