推荐产品
生物来源
rabbit
质量水平
抗体形式
serum
抗体产品类型
primary antibodies
克隆
polyclonal
种属反应性
human, rat, mouse
技术
immunohistochemistry: suitable
western blot: suitable
NCBI登记号
UniProt登记号
运输
wet ice
靶向翻译后修饰
unmodified
基因信息
human ... BGLAP(632)
mouse ... Bglap(12096)
rat ... Bglap(25295)
一般描述
骨钙素属于骨钙素/基质Gla蛋白家族。占骨蛋白总量的1~2%。它由成骨细胞制成，是非胶原骨基质的主要成分。它对钙具有高亲和力，并与磷灰石牢固结合。60%至90%的从头合成的骨钙素被掺入骨基质中，在基质矿化过程中它与羟基磷灰石结合。骨钙素的其余部分释放到循环中，可以作为骨形成的敏感标志物进行测量。血清中发现的骨钙素几乎完全来自骨形成，而吸收过程几乎没有贡献。主要作用于骨吸收的药物，例如双膦酸盐，会引起特定骨吸收标志物的快速下降，而骨钙素水平仅在延长治疗期后才会发生变化，这与骨形成标志物的预期动力学一致。在以骨转换增加为特征的疾病（例如骨质疏松症症、甲状旁腺功能亢进症症和Paget′s病）中，血清骨钙素水平升高；在与骨转换减少相关的疾病（例如甲状旁腺功能减退症症和生长激素缺乏症症）中，血清骨钙素水平降低。
特异性
抗体与骨钙素蛋白反应。
免疫原
合成肽对应于骨钙素蛋白的aa 59-74。
表位：aa 59-74
应用
使用经过验证可用于WB、IH的抗骨钙素抗体检测骨钙素。
质量
通过蛋白质印迹法对人心脏裂解液进行常规评估。
蛋白质印迹分析：
该抗体的1:500 - 1:5,000稀释液在10 μg人心脏裂解液中检测到骨钙素。
蛋白质印迹分析：
该抗体的1:500 - 1:5,000稀释液在10 μg人心脏裂解液中检测到骨钙素。
目标描述
计算值为11 kDa。
*观察到约22 kDa的条带。观察到的条带与预期条带之间的差异可能是由于翻译后修饰所致。
*观察到约22 kDa的条带。观察到的条带与预期条带之间的差异可能是由于翻译后修饰所致。
联系
替代品：MABD182
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
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