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主要文件

AB10527

Sigma-Aldrich

抗VDAC抗体

from rabbit, purified by affinity chromatography

别名:

voltage-dependent anion channel 1, Porin 31HL, Outer mitochondrial membrane protein porin 1, PORIN-31-HL, Porin 31HM, voltage-dependent anion-selective channel protein 1, Plasmalemmal porin

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About This Item

UNSPSC代码:
12352203
eCl@ss:
32160702

生物来源

rabbit

抗体形式

affinity isolated antibody

抗体产品类型

primary antibodies

克隆

polyclonal

纯化方式

affinity chromatography

种属反应性

rat, pig, mouse, human, horse

种属反应性（根据同源性预测）

rhesus macaque (based on 100% sequence homology), chimpanzee (based on 100% sequence homology), bovine (based on 100% sequence homology), equine (based on 100% sequence homology), porcine (based on 100% sequence homology)

包装

antibody small pack of 25 μg

技术

western blot: suitable

NCBI登记号

NP_003365

UniProt登记号

P21796

运输

ambient

基因信息

human ... VDAC1(7416)

一般描述

电压依赖性阴离子选择性通道蛋白1（也称为VDAC、VDAC1或线粒体外膜蛋白孔蛋白1）是己糖激酶和BCL2L1的线粒体外膜受体。VDAC可形成通过线粒体膜的通道，并参与小分子扩散、细胞体积调节和细胞凋亡。VDAC可能参与渗透性转换孔复合物（PTPC）的形成，该复合物负责线粒体产物的释放，从而触发细胞凋亡。

免疫原

对应于人VDAC的KLH偶联肽。

应用

研究子类别
凋亡-附加
研究类别
细胞凋亡 & 癌症
该抗Nkx2.1抗体经过验证可用于WB中，以用于检测VDAC。

质量

通过蛋白质印迹对 HepG2 细胞裂解液进行了评估。

蛋白质印迹分析：0.1 µg/ml该抗体可在10 µg的HepG2细胞裂解液中检测到VDAC

目标描述

观测值〜33 kDa

外形

亲和纯化
在含 0.1 M Tris-甘氨酸（pH 7.4），150 mM NaCl 和 0.05％ 叠氮化钠的缓冲液中的纯化的兔多克隆抗体。

储存及稳定性

自发运之日起，在 2-8°C 条件下可稳定保存1年

分析说明

对照
HepG2 细胞裂解液

其他说明

2024年CiteAb奖——成功的帕金森研究供应商(2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research)

免责声明

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

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储存分类代码

12 - Non Combustible Liquids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

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访问文档库

Khadija M Alawi et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(10), 4285-4298 (2015-07-03)
Transient receptor potential vanilloid 1 (TRPV1) is involved in sensory nerve nociceptive signaling. Recently, it has been discovered that TRPV1 receptors also regulate basal body temperature in multiple species from mice to humans. In the present study, we investigated whether
Joanne M Hildebrand et al.
Nature communications, 11(1), 3150-3150 (2020-06-21)
MLKL is the essential effector of necroptosis, a form of programmed lytic cell death. We have isolated a mouse strain with a single missense mutation, MlklD139V, that alters the two-helix 'brace' that connects the killer four-helix bundle and regulatory pseudokinase
Katerina Gkirtzimanaki et al.
Cell reports, 25(4), 921-933 (2018-10-26)
Interferon α (IFNα) is a prompt and efficient orchestrator of host defense against nucleic acids but upon chronicity becomes a potent mediator of autoimmunity. Sustained IFNα signaling is linked to pathogenesis of systemic lupus erythematosus (SLE), an incurable autoimmune disease
Valentina Condelli et al.
Oncotarget, 6(26), 22298-22309 (2015-06-19)
The HSP90 chaperone TRAP1 is translational regulator of BRAF synthesis/ubiquitination, since BRAF down-regulation, ERK signaling inhibition and delay of cell cycle progression occur upon TRAP1 silencing/inhibition. Since TRAP1 is upregulated in human colorectal carcinomas (CRCs) and involved in protection from
Kahli Zeitlow et al.
Biochimica et biophysica acta. Molecular basis of disease, 1863(11), 2973-2986 (2017-08-03)
A variable-length poly-T variant in intron 6 of the TOMM40 gene, rs10524523, is associated with risk and age-of-onset of sporadic (late-onset) Alzheimer's disease. In Caucasians, the three predominant alleles at this locus are Short (S), Long (L) or Very long
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