推荐产品
生物来源
rabbit
质量水平
抗体形式
purified antibody
抗体产品类型
primary antibodies
克隆
polyclonal
种属反应性
human, mouse
技术
immunohistochemistry: suitable (paraffin)
western blot: suitable
UniProt登记号
运输
wet ice
靶向翻译后修饰
unmodified
基因信息
human ... PACSIN1(29993)
一般描述
PACSINs, also known as syndapins, are a protein family consisting of three members that have been implicated in synaptic vesicular membrane trafficking and regulation of dynamin-mediated endocytotic processes (Cuajungco, 2006). It is presumed that all isoforms bind Dynamin, Synaptojanin 1 and N-WASP through their Src homology 3 domains. While PACSIN1 appears to be restricted to neural tissues, two PACSINs are more widespread with PACSIN2 being ubiquitously expressed and PACSIN3 present mainly in skeletal muscle, heart and lung (Modregger, 2001). PACSIN1 has been implicated as playing a central role in synaptic vesicle recycling (Kessels, 2004). Expected molecular weight is 51 kDa.
特异性
Reactivity with other species has not been tested.
The antibody recognizes human PACSIN1.
免疫原
KLH conjugated synthetic peptide selected from the N-terminal region of human PACSIN1.
应用
Anti-PACSIN1 Antibody, N-terminus detects level of PACSIN1 & has been published & validated for use in WB, IH(P).
质量
Evaluated on a representative lot by Western blot on mouse brain lysate using a 1:100 - 1:500 dilution of Anti-PACSIN1.
目标描述
~57 kDa
外形
Format: Purified
PBS containing 0.09% NaN3.
储存及稳定性
Maintain at 2-8ºC for up to 6 months from date of receipt. -20ºC is recommended for long term storage.
其他说明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
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储存分类代码
10 - Combustible liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Jens Stepan et al.
Cell reports, 41(10), 111766-111766 (2022-12-09)
Learning and memory rely on changes in postsynaptic glutamergic α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type receptor (AMPAR) number, spatial organization, and function. The Hippo pathway component WW and C2 domain-containing protein 1 (WWC1) regulates AMPAR surface expression and impacts on memory performance. However
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