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生物来源
rabbit
质量水平
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
纯化方式
affinity chromatography
种属反应性
rat, human, mouse
技术
immunocytochemistry: suitable
western blot: suitable
NCBI登记号
UniProt登记号
运输
wet ice
靶向翻译后修饰
unmodified
基因信息
human ... DBN1(1627)
一般描述
The developmentally-regulated neuron-specific protein, Drebrin A, is expressed first at the time of outgrowth and maturation of dendrites, and is localized within dendrites of the adult brain. Drebrin E+A- signals have been observed in the cell bodies of migrating neuroblasts in the core region; however, only fibrous and punctate drebrin E+A- signals were observed in postmigratory neuroblasts at the outer layers. Studies have demonstrated that the disappearance of drebrin E+A- signals from the cell body coincides with the cessation of neuronal migration. The disappearance of drebrin E from the cell body may be a molecular switch for the cessation of migration in newly generated neuroblast
特异性
Cat. # AB10140 detects the internal domain of Drebrin A/E.
May react with human based on sequence homology. Reactivity with other species has not been determined.
免疫原
Epitope: Internal Domain
KLH conjugated synthetic linear peptide.
应用
Detect Drebrin A/E using this Anti-Drebrin A/E Antibody validated for use in WB & IC.
Immunocytochemistry: Proven to react with Drebrin A/E in 16 DIV rat cortical neurons. Photo courtesy of Dr. Gang Lui, Drexel University.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Synapse & Synaptic Biology
Synapse & Synaptic Biology
质量
Western Blot:
A 1:5,000 dilution of this antibody was used to detect embryonic rat brain (day 16) tissue lysate.
A 1:5,000 dilution of this antibody was used to detect embryonic rat brain (day 16) tissue lysate.
目标描述
~77 kDa
外形
Antigen Affinity Purified
Purified rabbit polyclonal antibody in PBS with 0.05% NaN3.
储存及稳定性
Stable for 1 year at 2-8ºC from date of receipt.
分析说明
Control
Embryonic rat brain (day 16) tissue lysate.
Embryonic rat brain (day 16) tissue lysate.
其他说明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Jeffrey H Zimering et al.
PloS one, 11(7), e0159637-e0159637 (2016-07-22)
Early postnatal anesthesia causes long-lasting learning and memory impairment in rodents, however, evidence for a specific neurotoxic effect on early synaptogenesis has not been demonstrated. Drebrin A is an actin binding protein whose localization in dendritic protrusions serves an important
F Ciaffardini et al.
Cell death & disease, 5, e1268-e1268 (2014-05-31)
Cockayne syndrome (CS) is a progressive developmental and neurodegenerative disorder resulting in premature death at childhood and cells derived from CS patients display DNA repair and transcriptional defects. CS is caused by mutations in csa and csb genes, and patients
Kelsie Mozzoni LaBarbera et al.
Journal of neuroscience methods, 358, 109180-109180 (2021-04-10)
Mature primary neuronal cultures are an important model of the nervous system, but limited scalability has been a major challenge in their use for drug discovery of neurodegenerative diseases. This work describes a method for improving scalability through the use
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