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Merck
CN
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主要文件

安全信息

8.56057

Sigma-Aldrich

H-Pro-2-ClTrt resin

Novabiochem®

别名:

Chlorotrityl Resin

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About This Item

UNSPSC代码:
12352209
NACRES:
NA.22

质量水平

400

产品线

Novabiochem®

表单

beads

反应适用性

reaction type: Fmoc solid-phase peptide synthesis

制造商/商品名称

Novabiochem®

应用

peptide synthesis

储存温度

2-8°C

相关类别

一般描述

Pre-loaded resin for synthesis of protected peptide acids containing a C-terminal proline amino-acid residue by Fmoc SPPS. Cleavage of the protected peptide is effected by treatment with 1% TFA in DCM or 20% TFE in DCM. The use of this resin enables the synthesis of peptides containing C-terminal Pro without risk of diketopiperazine formation.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS

应用

  • B Yakimova et al. Reported the use of H-Pro-2-ClTrt resin in the synthesis of short peptides with potential ACE inhibitory activity (B Yakimova, et al., 2021).
  • S Wang et al. Detailed the use of H-Pro-2-ClTrt resin in a study on aminoacyl chain translocation catalysed by a type II thioesterase domain in an unusual non-ribosomal peptide synthetase (S Wang, et al., 2022).
  • LP Vu et al. Described the use of H-Pro-2-ClTrt resin in the synthesis of inhibitors for serine proteases (LP Vu, et al., 2022).

联系

Replaces: 04-12-2805

分析说明

Color (visual): pale yellow to beige
Appearance of substance (visual): beads
Identity (of the substitution): passes test
Loading (determined from the substitution of the Fmoc-Leu loaded resin): 0.30 - 1.10 mmol/g
Swelling Volume (in DMF): lot specific value
The polymer matrix is copoly (styrene - 1% DVB) 200 -400 mesh

法律信息

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

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储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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