REM resin (50-100 mesh)

Novabiochem^® 50-100 mesh REM resin ^[1] is an exceptionally high quality resin, designed specially for use in IRORI Kans and other parallel synthesis applications that require supports with reproducible substitution and swelling properties containing minimal leachable impurities. This material is derived from poly(chloromethylstyrene-styrene-divinylbenzene) manufactured to ISO 9001 standards. Unlike other Merrifield supports, which are prepared by chloromethylation of polystyrene, this matrix is prepared by co-polymerization of chloromethylstyrene, styrene and divinylbenzene. Since the amount of chloromethylstyrene added to the polymerization reaction can be precisely controlled, this leads to a highly defined resin with little batch to batch variation in functionality. The swelling characteristics of such resins are also more reproducible since the process of manufacture does not introduce additional cross-linking, as is the case with resins produced by chloromethylation. For applications of REM resin in SPOS see references ^[2-4].

Literature references

^[1] A. Brown, et al. (1997) J. Am. Chem. Soc., 119, 3288.
^[2] J. Cottney, et al. (1999) Bioorg. Med. Chem. Lett., 9, 1323.
^[3] A. Born, et al. (2001) Bioorg. Med. Chem. Lett., 11, 2351.
^[4] S. Caix-Haumesser, et al. (2001) Tetrahedron Lett., 42, 3721.

Replaces: 01-64-0393

Color (visual): white to yellow to beige
Appearance of substance (visual): beads
Loading (determined by elemental analysis of chlorine after derivatization with 4-chloro-benzylamine): 0.80 - 1.20 mmol/g
Swelling Volume (in DMF): lot specific result
The polymer matrix is copoly (styrene-1 % DVB), 50 - 100 mesh.

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany