NovaSyn^® TG hydroxy resin

NovaSynTG hydroxy resin is a composite of low cross-linked polystyrene and 3000-4000 M.W. polyethylene glycol, in which the ends of the PEG chains have been functionalized with hydroxyl groups. The 130 μm beads have a narrow size distribution, high diffusion rates and excellent swelling across a wide range of solvents from toluene to water ^[1,2,3], making them ideally suited to the synthesis of serial and parallel libraries by organic solid phase synthesis. This support has been used for the solid phase immobilization of carboxylic acids ^{[4,5,6,7,8,9]}, with cleavage by saponification with dilute aq. NaOH.

Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins

Literature references

^[1] W. Rapp, et al. in ′Innovation & Perspectives in Solid Phase Synthesis, 1st International Symposium′, R. Epton (Eds), SPCC UK Ltd., Birmingham, 1990, pp. 205.
^[2] L. Zhang, et al. in ′Peptides 1990, Proc. 21st European Peptide Symposium′, E. Giralt & D. Andreu (Eds), ESCOM, Leiden, 1990, pp.196.
^[3] E. Bayer (1991) Angew. Chem. Int. Ed. Engl., 30, 113.
^[4] M. Hiroshige, et al. (1995) Tetrahedron Lett., 36, 4567.
^[5] M. C. Fagnola, et al. (1997) Tetrahedron Lett., 38, 2307.
^[6] D. Fancelli, et al. (1997) Tetrahedron Lett., 38, 2311.
^[7] M. Patek, et al. (1995) Tetrahedron Lett., 36, 2227.
^[8] V. Krchnak, et al. (1995) Tetrahedron Lett., 36, 6193.
^[9] A. K. Szardenings & T. S. Burkoth (1997)Tetrahedron, 53, 6573.

Replaces: 01-64-0096

Color (visual): white to amber to beige
Appearance of substance (visual): beads
Loading (determined from the substitution of the Fmoc-Leu loaded resin): 0.20 - 0.30 mmol/g
Swelling Volume (in CH₂Cl₂): lot specific result
130 µm beads

NOVASYN is a registered trademark of Merck KGaA, Darmstadt, Germany

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany