H-Thr-Gly-NovaSyn^® TG resin

This resin is a useful tool for the synthesis of peptide aldehydes^[1]. Attachment of pre-formed amino acid aldehydes to this resin is effected by heating in 1% DIPEA in MeOH at 60 °C. Following chain extension using standard protocols, side-chain protecting groups can be removed with anhydrous TFA, prior to cleavage of the fully deprotected peptide aldehyde with MeCN/water/TFA. An analogous resin has been recently used to capture and purify peptide aldehydes generated by oxidation of peptide alcohols with IBX-polystyrene ^[2]. Novabiochem′s pre-loaded amino aldehyde resins can be found on page x.

Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins

Replaces: 04-12-3710

Color (visual): white to yellow to beige
Appearance of substance (visual): beads
Loading (determined from the substitution of the Fmoc- Oxybenzaldehyde loaded resin): 0.15 - 0.35 mmol/g
Identity (of the substitution): passes test
Swelling Volume (in DMF): lot specific result
The base resin is amino PEG-PS-copolymer (90 µm).

NOVASYN is a registered trademark of Merck KGaA, Darmstadt, Germany

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany