NovaSyn^®TG amino resin (130 µm)

Color (visual): white to yellow to beige
Appearance of substance (visual): beads
Loading (determined from the substitution of the Fmoc-Leu loaded resin): 0.20 - 0.30 mmol/g
Swelling Volume (in CH₂Cl₂): lot specific result
This resin is a composite of low-crossed linked polystyrene and 3000-4000 M.W. polyethylene glycol, which has been terminally amino functionalised. 130µm beads.

NovaSyn TG amino resin is a composite of low cross-linked polystyrene and 3000-4000 M.W. polyethylene glycol ^[1,2,3], in which the PEG chains have been terminally functionalized with an amino group. The 130 μm beads have a narrow size distribution, high diffusion rates and excellent swelling across a wide range of solvents from toluene to water, making them ideally suited to the synthesis of serial and parallel libraries by organic solid phase synthesis. This resin can be easily converted into other supports suitable for use in SPOS by acylation with the appropriate carboxylic acid-containing linker. For example, Hutchins and Chapman ^[4] have coupled Riniker′s HMPB linker to this resin and used it to prepare a range of ureas derived from glutamic acid.

Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins

Literature references

^[1] W. Rapp, et al. in ′Innovation & Perspectives in Solid Phase Synthesis, 1st International Symposium′, R. Epton (Eds), SPCC UK Ltd., Birmingham, 1990, pp. 205.
^[2] L. Zhang, et al. in ′Peptides 1990, Proc. 21st European Peptide Symposium′, E. Giralt & D. Andreu (Eds), ESCOM, Leiden, 1990, pp.196.
^[3] E. Bayer (1991) Angew. Chem. Int. Ed. Engl., 30,113.
^[4] S. M. Hutchins & K. T. Chapman (1994) Tetrahedron Lett., 35, 4055.

Replaces: 01-64-0094

NOVASYN is a registered trademark of Merck KGaA, Darmstadt, Germany

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany