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8.55008

Sigma-Aldrich

Sieber Amide resin

Novabiochem®

别名:

Sieber Amide resin, 9-Fmoc-amino-xanthen-3-yloxy-Merrifield resin

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1 EA
¥960.81

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1 EA
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About This Item

CAS号:
915706-90-0
MDL编号:
MFCD00039239
UNSPSC代码:
12352111
NACRES:
NA.22

¥960.81

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获取大包装报价

质量水平

400

产品线

Novabiochem®

表单

beads

反应适用性

reaction type: Fmoc solid-phase peptide synthesis

制造商/商品名称

Novabiochem®

应用

peptide synthesis

官能团

amine

储存温度

2-8°C

相关类别

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assay

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assay

99.9% trace metals basis

assay

99.9% trace metals basis

assay

99.99% trace metals basis (purity excludes ~2000 ppm zirconium.)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

impurities

≤200.0 ppm Trace Metal Analysis

impurities

≤550.0 ppm Trace Metal Analysis

impurities

≤1500.0 ppm Trace Metal Analysis

impurities

-

一般描述

A hyper acid-labile resin for the Fmoc SPPS of protected peptide amides via mild 1% TFA cleavage [1,2]. The resin can be readily reductively alkylated to provide a support suited to the synthesis of secondary carboxamides [3].This resin has also been employed to produce protected peptide fragments in which the C-terminal carboxylic acid group is blocked as a hydroxymethylphenoxy-β-alaninamide ester [4] .

Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins

应用

  • Determining the Hydrophobicity Index of Protected Amino Acids and Common Protecting Groups: Discusses the synthesis of peptide sequences using Sieber Amide resin for its acid-labile properties. (Gavva et al., 2023).
  • Smart biomaterials: Surfaces functionalized with proteolytically stable osteoblast-adhesive peptides: Utilizes Sieber Amide resin for surface functionalization techniques in biomaterials. (Zamuner et al., 2017).
  • A 99mTc-tricine-HYNIC-labeled peptide targeting the melanocortin-1 receptor for melanoma imaging: Describes the use of Sieber Amide resin in the synthesis of radiolabeled peptides for diagnostic imaging. (Shamshirian et al., 2016).

联系

Replaces: 01-64-0059

分析说明

Color (visual): white to light yellow to beige
Appearance of substance (visual): beads
Loading (Photometric determination of the Fmoc-chromophore liberated upon treatment with DBU/DMF): 0.40 - 0.80 mmol/g
Swelling Volume (in DMF): lot specific result
Swelling Volume (in CH₂Cl₂): lot specific result
Total swelling volume acc. Houben Weyl (in CH2Cl2): ≥ 5.2 ml/g
Total swelling volume acc. Houben Weyl (in DMF): ≥ 5.2 ml/g
The polymer matrix is copoly (styrene - 1% DVB) 100 -200 mesh

法律信息

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

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商品

Fmoc SPPS Linkers

Novabiochem® offers a wide range of linkers and derivatized resins for Fmoc solid-phase peptide synthesis with specialized protocols.

实验方案

Peptide Resin Loading Protocols

Review various resins like Merrifield, trityl-based, and hydroxymethyl-functionalized for peptide immobilization for diverse applications.

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