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Merck
CN
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主要文件

8.52351

Sigma-Aldrich

cis-Fmoc-Pro(4-N3)-OH

≥98.0% (HPLC), for peptide synthesis, Novabiochem®

别名:

cis-Fmoc-Pro(4-N3)-OH, Fmoc-(2S, 4S)-4-azidoproline

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About This Item

经验公式（希尔记法）:
C20H18N4O4
CAS号:
263847-08-1
分子量:
378.38
MDL编号:
MFCD04115792
UNSPSC代码:
12352209
NACRES:
NA.22

产品名称

cis-Fmoc-Pro(4-N3)-OH, Novabiochem®

质量水平

200

产品线

Novabiochem®

方案

≥98.0% (HPLC)

表单

powder

反应适用性

reaction type: Fmoc solid-phase peptide synthesis

制造商/商品名称

Novabiochem®

应用

peptide synthesis

官能团

azide

储存温度

15-25°C

SMILES字符串

[N+](=[N-])=N[C@@H]1CN([C@@H](C1)C(=O)O)C(=O)OCC2c3c(cccc3)c4c2cccc4

InChI

1S/C20H18N4O4/c21-23-22-12-9-18(19(25)26)24(10-12)20(27)28-11-17-15-7-3-1-5-13(15)14-6-2-4-8-16(14)17/h1-8,12,17-18H,9-11H2,(H,25,26)/t12-,18-/m0/s1

InChI key

HOPXMBBEYJTPNX-SGTLLEGYSA-N

相关类别

一般描述

A useful tool for the synthesis of branched, side-chain modified, cyclic peptides and peptide tools for click chemistry by Fmoc SPPS. The side-chain azido group is completely stable to piperidine and TFA, but can be readily converted to an amine on the solid phase or in solution by reduction with thiols [1] or phosphines[2,3].

Associated Protocols and Technical Articles
Guide to Selection of Orthogonally-Protected Building Blocks for Fmoc SPPS

Literature references

[1] M. Meldal, et al. (1997) Tetrahedron Lett., 38, 2531.
[2] J. T. Lundquist & J. C. Pelletier (2001) Org. Lett.,3, 781.
[3] N. Nepomniaschiy, et al. (2008) Org.Lett., 10, 5243.

分析说明

Colour (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Assay (HPLC, area%): ≥ 98.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble

法律信息

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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