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产品名称
Fmoc-Tyr(SO3nP)-OH, Novabiochem®
质量水平
产品线
Novabiochem®
方案
≥95.0% (HPLC)
表单
powder
反应适用性
reaction type: Fmoc solid-phase peptide synthesis
制造商/商品名称
Novabiochem®
应用
peptide synthesis
官能团
sulfonic acid
储存温度
-10 to -25°C
一般描述
A novel derivative for the synthesis of sulfotyrosine-containing peptides by Fmoc SPPS. The sulfate neopentyl group is stable to TFA, and thus protects the sulfotyrosine residue from degradation during the cleavage reaction, but is easily cleaved post-cleavage by treatment of the peptide with aqueous ammonium acetate [1].
Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Guide to Selection of Orthogonally -Protected Building Blocks for Fmoc SPPS
Literature references
[1] L. S. Simpson & T. S. Widlanski (2006) J. Am. Chem. Soc., 128, 1605.
[2] L. S. Simpson, et al. (2009) Chemistry & Biology, 16, 153.
Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Guide to Selection of Orthogonally -Protected Building Blocks for Fmoc SPPS
Literature references
[1] L. S. Simpson & T. S. Widlanski (2006) J. Am. Chem. Soc., 128, 1605.
[2] L. S. Simpson, et al. (2009) Chemistry & Biology, 16, 153.
分析说明
Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.0 % (a/a)
Purity (DC(BAW0)): ≥ 97 %
Assay (HPLC, area%): ≥ 95.0 % (a/a)
Solubility (1 mmole in 4 ml DMF): clearly soluble
To see the solvent systems used for TLC of Novabiochem® products please click here.
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.0 % (a/a)
Purity (DC(BAW0)): ≥ 97 %
Assay (HPLC, area%): ≥ 95.0 % (a/a)
Solubility (1 mmole in 4 ml DMF): clearly soluble
To see the solvent systems used for TLC of Novabiochem® products please click here.
法律信息
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
实验方案
We provide an overview of our available reagents, together with recommendations and details of their use for synthesis of peptides containing post-translationally modified amino acids.
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